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Evaluation of Kd Values from US Patent US20240059728: "NOVEL GALACTOSIDE INHIBITOR OF GALECTINS"
Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryRelated BioAssays by Target
Binding affinity to human Gal-1 assessed as decrease in Gal-1 levels by ELISA
Assay data:1 Tested
Binding affinity to Gal-1 (unknown origin) by SPR analysis
Binding affinity to Gal-1 (unknown origin) assessed as equilibrium constant by SPR analysis
Assay data:3 Tested
Binding affinity to Gal-1 (unknown origin) incubated for 30 mins by RP-HPLC analysis
Binding affinity to Gal-1 (unknown origin) by fluorescence spectroscopy
Assay data:6 Tested
Biological Assay from US Patent US20230348442: "GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES"
Assay data:176 Active, 169 Activity ≤ 1 µM, 176 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Evaluation of Compound Inhibitory Activity (IC50) from US Patent US20230295182: "SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES"
Assay data:115 Active, 112 Activity ≤ 1 µM, 115 Tested
Antagonist activity against human US7 patient-derived BCP-ALL cells assessed as inhibition of galectin-1-mediated cell-cell cluster formation at 500 uM incubated for 2 hrs by phase contrast microscopy
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity against human TXL2 patient-derived BCP-ALL cells assessed as inhibition of galectin-1-mediated cell-cell cluster formation at 500 uM incubated for 2 hrs by phase contrast microscopy
Binding affinity to human galectin-1 by fluorescence polarization analysis
Binding affinity to human galectin-1 using 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-y1]-3'.(3,5-dimethoxy-benzamido)-1,1'-sulfanediyl-di-beta-D-galactopyranoside as fluorescent probe by fluorescence polarization analysis
Assay data:5 Tested
Inhibition of Alexa-Fluor-488 conjugated galectin-1 binding to human osteoarthritic cartilage at 4 mM of sugar preincubated for 1 hr followed by incubation with tissue material for overnight by 2-colour fluorescence microsocopy
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Alexa-Fluor-488 conjugated galectin-1 binding to C57BL/6 mouse kidney medulla at 2 mM of sugar preincubated for 1 hr followed by incubation with tissue material for overnight by 2-colour fluorescence microsocopy
Assay data:1 Active, 1 Tested
Inhibition of Alexa-Fluor-488 conjugated galectin-1 binding to C57BL/6 mouse kidney cortex at 2 mM of sugar preincubated for 1 hr followed by incubation with tissue material for overnight by 2-colour fluorescence microsocopy
Inhibition of biotinylated galectin-1 binding to C57BL/6 mouse kidney at 125 to 500 uM of lactose residue per molecule preincubated for 1 hr followed by incubation with tissue material for overnight by light microsocopy
Assay data:3 Active, 3 Tested
Inhibition of His-tagged recombinant human Gal-1 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescence based assay
Assay data:8 Active, 9 Tested
Binding affinity to recombinant rat Galectin-1 expressed in Escherichia coli assessed as dissociation constant by fluorescence polarization
Inhibition in human Gal-1
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
fluorescence anisotropy assay from US Patent US11046725: "Galactoside inhibitor of galectins"
Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested
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