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Antagonist activity at human RARG in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:5 Active, 36 Tested
SummaryRelated BioAssays by Target
Agonist activity at human RARG in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:1 Active, 38 Tested
Antagonist activity at human RARB in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:3 Active, 36 Tested
Agonist activity at human RARB in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Antagonist activity at human RARA in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:36 Tested
Agonist activity at human RARA in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Agonist activity at human RAR-alpha assessed as receptor transactivation at 500 to 20000 nM incubated for 24 hrs by luciferase reporter gene assay
Assay data:1 Tested
Agonist activity at human RAR-alpha assessed as receptor transactivation incubated for 24 hrs by luciferase reporter gene assay
Activation of RARalpha (unknown origin) at 10 uM
Antagonist activity at Gal4-RARalpha transfected in HEK293 cells assessed as atRA-induced RARalpha transactivation and measured after 6 hrs by Dual-Light chemiluminiscence assay
Assay data:1 Active, 1 Tested
Agonist activity at human RAR-beta expressed in CHO-K1 cells by PathHunter assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human RAR-alpha expressed in CHO-K1 cells by PathHunter assay
Agonist activity at human RAR-beta expressed in CHO-K1 cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to 9-cis-retinoic acid
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human RAR-alpha expressed in CHO-K1 cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to 9-cis-retinoic acid
Agonist activity at human RAR-beta2 receptor
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human RARbeta (177 to 455 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Agonist activity at human RARgamma (177 to 462 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Agonist activity at human RARalpha (177 to 462 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Agonist activity at human GAL4 DBD-fused RARalpha LBD (177 to 462 residues) transfected in HEK293T cells assessed as fold activation at 10 uM incubated for 14 to 16 hrs by Renilla/Firefly dual-luciferase reporter assay
Transactivation assays from US Patent US10752616: "Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists"
Assay data:46 Active, 2 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 46 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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