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Purinergic P2Y Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human P2Y14 expressed in CHO cells assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human recombinant P2Y14 assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human P2Y14 using UDP-Glc as substrate
Assay data:1 Active, 1 Tested
Agonist activity at human P2Y14 expressed in rat CHO cells
Agonist activity at human P2Y14 expressed in rat C6 cells
Agonist activity at human P2Y14 expressed in HEK293 cells
Antagonist activity at rat P2Y14
Antagonist activity at P2Y14 (unknown origin) assessed as binding constant
Selectivity interaction (Binding assay (using HEK293 cells)) EUB0000274bCl P2RY14
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (FLIPR assay) EUB0000337aCl P2RY14
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Biochemical interaction (FLIPR assay) EUB0000274bCl P2RY14
Affinity On-target Cellular interaction (Binding assay in HEK293 cells) EUB0000337aCl P2RY14
Affinity On-target Cellular interaction (Fold potentiation assay (addition of EC20 acetylcholine; in human M1 expressing Chinese hamster ovary (CHO) cells; using calcium mobilization readout on a fluorometric imaging plate reader (FLIPR384))) EUB0000274bCl P2RY14
Antagonist activity at P2Y14R (unknown origin) expressed in rat C6 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 15 mins in presence of IBMX by chromatography
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of fluorescent antagonist binding to human P2Y14R expressed in HEK293 cells at 3 uM preincubated for 30 mins followed by 4-(4-(1-(4-(4-(3-(3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thioureido)butanamido)butanoyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid addition and measured after 30 mins by flow cytometry analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at P2Y14R (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated in presence of IBMX by cAMP-glo assay
Assay data:26 Active, 26 Activity ≤ 1 µM, 50 Tested
Antagonist activity at P2Y14R (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation at 100 nM incubated in presence of IBMX by cAMP-glo assay relative to control
Assay data:50 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human P2Y14R expressed in human HEK293 cells assessed as inhibition of cAMP level incubated for 30 mins by cAMP-glo assay
Assay data:25 Active, 25 Activity ≤ 1 µM, 46 Tested
Antagonist activity at human P2Y14R expressed in human HEK293 cells assessed as inhibition of cAMP level at 100 nM incubated for 30 mins by cAMP-glo assay relative to control
Assay data:46 Tested
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