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Inhibition of SYK (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of SYK in human Ramos cells assessed as reduction in anti IgM-induced phosphorylation of BLNK by flow cytometry assay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of human SYK using 5-Fluo-Ahx-GAPDYENLQELNKK-Amid as substrate in presence of ATP by microfluidic mobility shift assay
Assay data:10 Active, 10 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of SYK (unknown origin) at 1 uM relative to control
Inhibition of SYK (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human Syk expressed in Kluyveromyces lactis using Biot-(BA)3-DEEYEIP-NH2 as substrate in presence of ATP by HTRF assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of SYK (unknown origin) using biotinylated EDPDYEWPSA as substrate incubated for 30 mins in presence of 33P-ATP by Scintillation Proximity Assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of SYK (unknown origin) by Ambit kinase assay
Assay data:4 Tested
SYK Inhibition from US Patent US20230295171: "FUSED HETEROAROMATIC PYRROLIDINONES"
Assay data:124 Active, 5 Activity ≤ 1 nM, 106 Activity ≤ 1 µM, 128 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
High Throughput Syk Biochemical Assay from US Patent US11517570: "Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b SYK
Selectivity interaction (ScanMAX (DiscoverX)) EUB0000232b SYK
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a SYK
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000305b SYK
Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000153b SYK
Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000714a SYK
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000704a SYK
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity On-target Cellular interaction (Cellular human mast cell degranulation assay) EUB0000714a SYK
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