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Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Tachykinin NK1 Eurofins Panlabs panel
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
Assay data:79 Tested
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
Assay data:19 Active, 4 Activity ≤ 1 µM, 218 Tested
Inhibition of tachykinin NK1 receptor (unknown origin) upto 10000 nM
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Binding affinity to human neurokinin receptor 1 expressed in CHO cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells at 1 uM relative to control
Assay data:2 Tested
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
Assay data:10 Active, 5 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Human NK-2 Binding Assay from US Patent US11731974: "N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
Assay data:1 Active, 44 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Human NK-1 Binding assay from US Patent US11731974: "N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
Assay data:44 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Binding Competition Assay with Human NK-3 Receptor from US Patent US11731974: "N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
Assay data:47 Active, 47 Activity ≤ 1 µM, 47 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b TACR2
Assay data:1 Active, 1 Tested
Selectivity interaction (CEREP Wide Ligand screening panel (ion channels, receptors, enzymes)) EUB0000304b TACR1
Selectivity interaction (CEREP panel (ligand receptors, ion channels, transporters)) EUB0000330a TACR2
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