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Inhibition of human CYP11B1
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Affinity On-target Cellular interaction (HTRF-based assay (V79 cell lines, CisBio)) EUB0000733a CYP11B2
Assay data:1 Tested
Affinity On-target Cellular interaction (HTRF-based assay (V79 cell lines, CisBio)) EUB0000313b CYP11B2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human CYP11B2 expressed in V79 cells using 11-deoxycorticosteron as substrate preincubated for 1 hr followed by substrate addition and measured after 3 hrs by HPLC analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human CYP11B1 expressed in V79 cells using 11-deoxycorticosteron as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by HPLC analysis
Inhibition of rat CYP11B1
Inhibition of human CYP11B1 expressed in Chinese hamster V79 MZh cells using [14C]-deoxycorticosteron as substrate measured after 6 hrs by phosphoimager analysis
Assay data:37 Active, 37 Activity ≤ 1 µM, 37 Tested
Inhibition of human CYP11B2 expressed in Chinese hamster V79 MZh cells using [14C]-deoxycorticosteron as substrate measured after 6 hrs by phosphoimager analysis
Assay data:37 Active, 1 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 37 Tested
Enzyme Assay from US Patent US11040034: "Metalloenzyme inhibitor compounds"
Assay data:133 Active, 113 Activity ≤ 1 µM, 135 Tested
Inhibition of Cortisol Synthesis from US Patent US10858342: "Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases"
Assay data:112 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Aldosterone Synthase from US Patent US10858342: "Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases"
Assay data:112 Active, 112 Activity ≤ 1 µM, 112 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
G402-Based Assay from US Patent US9458135: "Dihydroquinoline-2-one derivatives"
Assay data:30 Active, 20 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
Cellular Inhibition Assay from US Patent US9394290: "Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases"
Assay data:44 Active, 1 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 46 Tested
Cellular Enzyme Assay from US Patent US9353081: "Bicyclic dihydroquinoline-2-one derivatives"
Assay data:46 Active, 41 Activity ≤ 1 µM, 46 Tested
V79-Human-CYP11B2 and V79-Human-CYP11B1 Assays from US Patent US9351973: "Pyrazolopyridyl compounds as aldosterone synthase inhibitors"
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
In Vitro Inhibition Assay from US Patent US9271963: "Selective inhibitors of human corticosteroid synthases"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition Assay from US Patent US9271963: "Selective inhibitors of human corticosteroid synthases"
Assay data:27 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested
Inhbition Assay from US Patent US9278093: "Aldosterone synthase inhibitors"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Cellular Enzyme Assay from US Patent US9187429: "Phenyl-tetrahydroisoquinoline derivatives"
Assay data:72 Active, 1 Activity ≤ 1 nM, 69 Activity ≤ 1 µM, 72 Tested
CYP11B1 Inhibition Assay from Article 10.1021/jm800355c: "Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer."
Assay data:16 Active, 12 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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