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Submitochondrial Particle Assay from US Patent US9713651: "Compositions, methods, and systems for the synthesis and use of imaging agents"
Assay data:38 Active, 53 Activity ≤ 1 µM, 55 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1% O2-induced HIF1 activation incubated for 30 mins prior to 1% O2-challenge measured after 16 hrs by luciferase reporter assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1,10-phenanthroline-induced HIF1 activation incubated for 30 mins prior to 1,10-phenanthroline-challenge measured after 16 hrs by luciferase reporter assay
Assay data:4 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1,10-phenanthroline-induced HIF1 activation at 30 uM incubated for 30 mins prior to 1,10-phenanthroline-challenge measured after 16 hrs by luciferase reporter assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1% O2-induced HIF1 activation at 30 uM incubated for 30 mins prior to 1% O2-challenge measured after 16 hrs by luciferase reporter assay
Inhibition of NADH-ubiquinone oxidoreductase assessed as NADH oxidase activity in bovine heart submitochondrial particles
Assay data:8 Active, 3 Activity ≤ 1 µM, 17 Tested
Inhibition of bovine mitochondrial NADH-ubiquinone oxidoreductase by NADH oxidase assay
Assay data:13 Active, 11 Activity ≤ 1 µM, 13 Tested
Relative potency of inhibition of NADH oxidase (IC50); 4-dehydroxy-4-hydroxylimonorolliniastatin-1 as standard
Assay data:23 Tested
Inhibitory concentration against NADH oxidase
Assay data:4 Active, 4 Tested
Maximum inhibition (2 uM) halve the control NADH oxidase activity in bovine heart submitochondrial particles (SMP)
Inhibition of NADH oxidase activity.
Assay data:23 Active, 14 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested
Inhibitory concentration needed to halve the control NADH oxidase activity in bovine heart submitochondrial particles (SMP)
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heart
Assay data:14 Active, 10 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
Concentration required for the inhibition of NADH oxidase in submitochondrial particles from beef heart
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Compound was tested for NADH oxidase activity in bovine heart submitochondrial particles
Assay data:2 Active, 2 Tested
Inhibitory potency against NADH oxidase with respect to compound 2c
Assay data:10 Tested
Inhibitory activity against NADH oxidase in beef heart mitochondrial complex I.
Assay data:10 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of complex I activity was determined by NADH oxidase assay using bovine heart submitochondrial particles.
Assay data:5 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested
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