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Biochemical EC50 Assay from US Patent US20240050576: "METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE"
Assay data:51 Active, 61 Activity ≤ 1 µM, 61 Tested
SummaryRelated BioAssays by Target
Binding affinity to human TNF-alpha assessed as binding constant (Koff) by SPR assay
Assay data:2 Tested
Binding affinity to human TNF-alpha assessed as binding constant (Kon) by SPR assay
Binding affinity to human TNF-alpha assessed as dissociation constant by SPR assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of TNFalpha in LPS-stimulated human mononuclear cell line by radioimmunoassay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human TNF-alpha secretion stimulated by LPS
Inhibition of TNF-alpha (unknown origin) by ELISA assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 7 Tested
Inhibition of IL-6 (unknown origin) by ELISA assay
Assay data:6 Active, 3 Activity ≤ 1 µM, 7 Tested
Inhibition of human GAPDH
Assay data:1 Tested
Irreversible inhibition of GAPDH (unknown origin) assessed as ratio of Kinact/Ki
Assay data:4 Tested
Inhibition of GAPDH (unknown origin) measured after 1 hr
Inhibition of rabbit muscle GAPDH at 0.5 mM incubated for 24 hrs relative to control
Irreversible inhibition of GAPDH (unknown origin) assessed as ratio of Kinact/Ki at slow phase
Irreversible inhibition of GAPDH (unknown origin) assessed as ratio of Kinact/Ki at fast phase
Inhibition of mouse TNF-alpha in mouse L929 cells incubated for 18 hrs by CellTitreGlo assay
Inhibition of human TNF-alpha assessed as dissociation constant incubated for 5 hrs by SPR analysis
Inhibition of human TNF-alpha assessed as dissociation constant by ELISA assay
In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of IL-6 (unknown origin) relative to control
SummaryPubMed CitationRelated BioAssays by Target
TNF-alpha RELEASE from US Patent US11365204: "Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors"
Assay data:67 Active, 71 Activity ≤ 1 µM, 71 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
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