Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Potency index, ratio of IC50 of pargyline to IC50 for test compound for inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in NADH oxidation incubated for 1 hr
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 10 uM in presence of proline by IncuCyte imaging system based assay relative to control
Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at 10 uM in presence of proline by IncuCyte imaging system based assay relative to control
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 10 uM in absence of proline by IncuCyte imaging system based assay relative to control
Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at 10 uM in absence of proline by IncuCyte imaging system based assay relative to control
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline M+5 content at 5 uM incubated for 24 hrs in presence of [U-13C]-glutamine by LC-MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content by LC-MS analysis relative to control
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content at 1 uM by LC-MS analysis relative to control
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content at 100 uM by LC-MS analysis relative to control
Inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in NADH oxidation incubated for 1 hr
Assay data:3 Active, 61 Tested
Binding affinity to PYCR1 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to PYCR2 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to PYCR2 in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on