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Binding affinity to mouse colon mucosal epithelium TRPM5 assessed as increase in short circuit current
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human TRPM5 expressed in human Caco-2 cells assessed as increase in acetylcholine release at 50 uM incubated for 18 hrs in the presence of N'-(3,4-dimethoxybenzylidene)-2-(naphthalen-1-yl)acetohydrazide by mass spectrometric analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human TRPM5 expressed in human Caco-2 cells assessed as increase in acetylcholine release at 50 uM incubated for 18 hrs in the presence of N'-(3,4-dimethoxybenzylidene)-2-phenylcyclopropanecarbohydrazide by mass spectrometric analysis
Agonist activity at human TRPM5 expressed in human Caco-2 cells assessed as increase in acetylcholine release at 50 uM incubated for 18 hrs by mass spectrometric analysis
Assay data:2 Active, 2 Tested
Agonist activity at mouse TRPM5 expressed in CHO-K1 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human TRPM5 expressed in CHO-K1 cells assessed as increase in relative fluorescence unit measured for 2 mins by FLIPR based membrane potential assay
Assay data:24 Active, 15 Activity ≤ 1 µM, 35 Tested
Agonist activity at human TRPM5 in HEK293T cells by FLIPR based assay
Assay data:1 Tested
Agonist activity at human TRPM5 expressed in HEK cells by whole cell electrophysiology method
Antagonist activity at TRPM5 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at TRPM5 (unknown origin)
Agonist activity at mouse TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Agonist activity at human TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by QPatch HTX assay
Agonist activity at human TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assay
Assay data:46 Active, 25 Activity ≤ 1 µM, 72 Tested
Agonist activity at human TRPM5 expressed in HEK293 cells assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay
Assay data:4 Tested
Inhibition of human TRPM5 expressed in HEK293 cells assessed as decrease in carbachol-evoked membrane depolarization at 22 uM preincubated for 2 mins followed by carbachol addition measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay relative to control
Mouse TRPM5 (Transient Receptor Potential channels)
Human TRPM5 (Transient Receptor Potential channels)
Assay data:3 Active, 3 Tested
Activation of TRPM5 in SV40 expressing transgenic mouse Beta-TC-6 cells assessed as induction of 1 mM glucose-mediated insulin secretion after 2 hrs by ELISA
SummaryRelated BioAssays by Target
Activation of TRPM5 in SV40 expressing transgenic mouse Beta-TC-6 cells assessed as induction of 0.3 mM glucose-mediated insulin secretion at 0.03 to 3 uM after 2 hrs by ELISA
Activation of TRPM5 in mouse GLUTag cells assessed as induction of 0.3 mM glucose-mediated GLP-1 secretion after 2 hrs by ELISA
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