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PROTAC activity at VHL/HiBit-tagged BRD7 in HEK293 cells assessed as BRD7 protein degradation pre-incubated with endurazine for 2.5 hrs followed by compound addition and measured after 24 hrs by live cell kinetics assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as maximal degradation by Western blot analysis relative to control
Assay data:1 Tested
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 100 nM incubated for 48 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 10 nM incubated for 48 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as degradation of BRD7 protein incubated for 8 hrs by Western blot analysis
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 1 nM incubated for 2 hrs by Western blot analysis relative to control
Assay data:2 Tested
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 10 nM incubated for 2 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 100 nM incubated for 2 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 10000 nM incubated for 2 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 0.1 nM incubated for 8 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 1 nM incubated for 8 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 10 nM incubated for 8 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 100 nM incubated for 8 hrs by Western blot analysis relative to control
PROTAC activity at CRBN/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 1 uM incubated for 8 hrs by Western blot analysis relative to control
PROTAC activity at CRBN/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 1 uM incubated for 2 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 1 uM incubated for 8 hrs by Western blot analysis relative to control
Assay data:3 Tested
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 1 uM incubated for 2 hrs by Western blot analysis relative to control
Assay data:20 Tested
PROTAC activity at VHL/BRD7 in human HeLa cells assessed as protein degradation at 1 uM incubated for 16 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human HeLa cells assessed as protein degradation at 1 uM incubated for 4 hrs by Western blot analysis relative to control
PROTAC activity at DCAF15/BRD7 in human HeLa cells assessed as remaining BRD7 protein level at 1 uM incubated for 16 hrs by Western blot analysis relative to control
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