Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Selectivity interaction (Binding assay (using HEK293 cells)) EUB0000274bCl P2RY14
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (FLIPR assay) EUB0000337aCl P2RY14
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Biochemical interaction (FLIPR assay) EUB0000274bCl P2RY14
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Affinity On-target Cellular interaction (Binding assay in HEK293 cells) EUB0000337aCl P2RY14
Affinity On-target Cellular interaction (Fold potentiation assay (addition of EC20 acetylcholine; in human M1 expressing Chinese hamster ovary (CHO) cells; using calcium mobilization readout on a fluorometric imaging plate reader (FLIPR384))) EUB0000274bCl P2RY14
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at P2Y14R (unknown origin) expressed in rat C6 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 15 mins in presence of IBMX by chromatography
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of fluorescent antagonist binding to human P2Y14R expressed in HEK293 cells at 3 uM preincubated for 30 mins followed by 4-(4-(1-(4-(4-(3-(3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thioureido)butanamido)butanoyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid addition and measured after 30 mins by flow cytometry analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at P2Y14R (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated in presence of IBMX by cAMP-glo assay
Assay data:26 Active, 26 Activity ≤ 1 µM, 50 Tested
Antagonist activity at P2Y14R (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation at 100 nM incubated in presence of IBMX by cAMP-glo assay relative to control
Assay data:50 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human P2Y14R expressed in human HEK293 cells assessed as inhibition of cAMP level incubated for 30 mins by cAMP-glo assay
Assay data:25 Active, 25 Activity ≤ 1 µM, 46 Tested
Antagonist activity at human P2Y14R expressed in human HEK293 cells assessed as inhibition of cAMP level at 100 nM incubated for 30 mins by cAMP-glo assay relative to control
Assay data:46 Tested
Inhibition of fluorescent antagonist binding to human P2Y14 expressed in CHO cells incubated for 30 mins
Antagonist activity at human P2Y14 expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP accumulation incubated for 15 mins in presence of IBMX
Inhibition of fluorescent antagonist binding to human P2Y14R expressed in CHO cells preincubated for 30 mins followed by 6-amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy 6-(4-(trifluoromethyl)phenyl)naphthalen-1-yl)phenyl)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)phenyl)-3-iminio-5-sulfo-3H-xanthene-4-sulfonate addition and measured after 30 mins by BD FACSCalibur flow cytometry analysis
Assay data:40 Active, 39 Activity ≤ 1 µM, 40 Tested
PRESTO-Tango GPCRome screening (P2RY14)
Binding assay with 2% HSA
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Binding assay (no HSA)
FLIPR assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
P2Y CEREP ligand profiling
P2Y-purinergic receptor CEREP ligand profiling
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on