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Biochemical Assay from US Patent US11680056: "MK2 inhibitors and uses thereof"
Assay data:29 Active, 17 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Enzyme panel (Invitrogen)) EUB0000730a MAPKAPK2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b MAPKAPK2
Selectivity interaction (Enzymatic assay) EUB0000624a MAPKAPK2
Affinity Biochemical interaction (Enzymatic activity assay (Ustate kinase profiler Service; Millipore)) EUB0000056c MAPKAPK2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity On-target Cellular interaction (Western Blot (phosphorylation of the MK2 substrate HSP27 in U937 cells)) EUB0000056c MAPKAPK2
Affinity Phenotypic Cellular interaction (Cell-based TNFa assay (MesoScale Discovery; inhibition of LPS stimulated TNFa production in human U937 cells)) EUB0000056c MAPKAPK2
Thermal Shift Assay. Domain: start/stop: H47-K353
Assay data:27 Tested
Inhibition of MAPKAPK2 (unknown origin) at 1 uM in presence of ATP by Z'-LYTE assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human MAPKAPK2 (46 to end residues) assessed as residual activity at 1 uM using KKLNRTLSVA as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillation counting method relative to control
Inhibition of human MAPKAPK2 assessed as residual activity at 30 uM relative to control
Inhibition of human MK2
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MAPKAPK2 (unknown origin) at 1 uM by DiscoverX KINOMEscan assay
Inhibition of MK2 in Escherichia coli -stimulated human THP-1 cells assessed as reduction in p38alpha MAPK phosphorylation at 1 uM pretreated for 1 hr followed by Escherichia coli stimulation and measured up to 15 mins by western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MK2 in Escherichia coli -stimulated human THP-1 cells assessed as reduction in p38alpha MAPK phosphorylation at 5 uM pretreated for 1 hr followed by Escherichia coli stimulation and measured up to 15 mins by western blot analysis
Inhibition of MAPKAPK2 (unknown origin) at 0.5 uM relative to control
MAPKAPK2 DiscoveRx kinase panel
MAPKAPK2 SGC Tm panel (DSF)
MAPKAP-K2(h) Kinase panel
MAPKAP-K2(h) Millipore kinase panel
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