Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
In Vitro DGAT2 Assay from US Patent US20230405002: "COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR"
Assay data:19 Active, 16 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
DGAT2 Enzymatic Activity Assay from US Patent US11787810: "Diacylglyceride O-acyltransferase 2 inhibitors"
Assay data:129 Active, 3 Activity ≤ 1 nM, 121 Activity ≤ 1 µM, 134 Tested
Measurement of Inhibitory Effect Against DGAT2 Enzyme Activity from US Patent US20230322706: "NOVEL BIARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF"
Assay data:32 Active, 23 Activity ≤ 1 µM, 32 Tested
Inhibition of recombinant human DGAT2 expressed in Sf9 cell membrane assessed as inhibition of triglyceride synthesis at 10 uM for 1 hr by LC-MS-based mass spectrophotometric analysis
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human DGAT2 expressed in sf9 insect cell membrane assessed as reduction in 13C18-triolein product formation using 13C oleoyl-CoA as substrate by LC-MS/MS analysis
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of DGAT2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into triacylglycerol preincubated for 5 to 180 mins followed by substrate addition by rapid dilution assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into triacylglycerol preincubated for 120 mins followed by substrate addition and measured after 40 mins by scintillation counting method
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
In Vitro DGAT2 Assay and Determination of IC50 Values for DGAT2 Inhibitors from US Patent US11471458: "Diacylglycerol acyl transferase 2 inhibitor"
Assay data:25 Active, 22 Activity ≤ 1 µM, 27 Tested
DGAT2 enzymatic activity assay from WIPO Patent WO2022076495: "PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS"
Assay data:128 Active, 2 Activity ≤ 1 nM, 120 Activity ≤ 1 µM, 141 Tested
Enzymatic Activity Assay from US Patent US11104690: "Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2"
Assay data:199 Active, 199 Activity ≤ 1 µM, 199 Tested
In Vitro Assay from US Patent US11065249: "Diacylglycerol acyl transferase 2 inhibitor"
Assay data:24 Active, 22 Activity ≤ 1 µM, 26 Tested
In Vitro Assay from US Patent US11034678: "Diacylglycerol acyl transferase 2 inhibitors"
Assay data:16 Active, 16 Activity ≤ 1 µM, 16 Tested
DGAT2 Enzymatic Activity Assay from US Patent US10947222: "Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2"
Assay data:72 Active, 7 Activity ≤ 1 nM, 72 Activity ≤ 1 µM, 72 Tested
Enzymatic Activity Assay from US Patent US10568876: "Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2"
Assay data:138 Active, 1 Activity ≤ 1 nM, 78 Activity ≤ 1 µM, 138 Tested
DGAT2 Cell-Based Assay from US Patent US9296745: "Diacylglycerol acyltransferase 2 inhibitors"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro DGAT2 Assay from US Patent US9296745: "Diacylglycerol acyltransferase 2 inhibitors"
Assay data:210 Active, 182 Activity ≤ 1 µM, 213 Tested
Enzymatic Activity Assay from US Patent US9828369: "Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2"
Assay data:166 Active, 70 Activity ≤ 1 µM, 166 Tested
In Vitro DGAT2 Assay from US Patent US9789110: "Diacylglycerol acyltransferase 2 inhibitors"
Assay data:55 Active, 1 Activity ≤ 1 nM, 55 Activity ≤ 1 µM, 55 Tested
In Vitro DGAT2 Assay from US Patent US10188653: "Diacylglycerol acyltransferase 2 inhibitors"
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on