Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of XPO1 in human MM1.S cells at 0.1 to 10 uM incubated for 2 hrs by confocal microscopic analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Competitive inhibition of recombinant XPO1 (unknown origin) at 10 uM pretreated for 1 hr in presence of KPT-330 by Rhodamine-N3 dye based Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to wild type human CRM1 transfected HeLa cells assessed as inhibition of nuclear export of cargoes at 10 uM incubated for 12 hrs by confocal microscope analysis
Binding affinity to wild type human CRM1 transfected HeLa cells assessed as inhibition of nuclear export of cargoes at 2 uM incubated for 12 hrs by confocal microscope analysis
Binding affinity to Cy3 dye-labelled human CRM1 assessed as dissociation constant in absence of RanGTP at 10 uM incubated for 1 hr by micro-scale thermophoresis analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MBP-NES PKI binding to human CRM1 in presence RanGTP at 20 uM by pull down assay
Inhibition of human CRM1-WT assessed as C528 conjugation at 1 uM incubated for 2 hrs before binding by coomassie blue staining based pull-down assay
Inhibition of human CRM1-C528S mutant assessed as C528 conjugation at 20 uM incubated for 2 hrs before binding by coomassie blue staining based pull-down assay
Assay data:3 Active, 3 Tested
Inhibition of human wild type CRM1 assessed as C528 conjugation at 20 uM incubated for 2 hrs before binding by coomassie blue staining based pull-down assay
Induction of CRM1 degradation in human MGC-803 cells assessed as reduction in CRM1 expression at 5 uM measured after 24 hrs in presence of proteasome inhibitor bortezomib by Western blot analysis
Induction of CRM1 degradation in human HGC-27 cells assessed as reduction in CRM1 expression at 5 uM measured after 24 hrs in presence of proteasome inhibitor bortezomib by Western blot analysis
Induction of CRM1 degradation in human MGC-803 cells assessed as reduction in CRM1 expression at 5 uM measured after 24 hrs in presence of proteasome inhibitor MG132 by Western blot analysis
Induction of CRM1 degradation in human HGC-27 cells assessed as reduction in CRM1 expression at 5 uM measured after 24 hrs in presence of proteasome inhibitor MG132 by Western blot analysis
Induction of CRM1 degradation in human MGC-803 cells assessed as reduction in CRM1 expression at 5 uM measured after 24 hrs by Western blot analysis
Induction of CRM1 degradation in human HGC-27 cells assessed as reduction in CRM1 expression at 5 uM measured after 24 hrs by Western blot analysis
Induction of CRM1 degradation in human MGC-803 cells assessed as increase in Ranbp1 accumulation in nucleus at 10 uM measured after 6 hrs by DAPI staining based immunofluorescence assay
Induction of CRM1 degradation in human MGC-803 cells assessed as increase in p53 accumulation in nucleus at 10 uM measured after 6 hrs by DAPI staining based immunofluorescence assay
Induction of CRM1 degradation in human MGC-803 cells assessed as reduction in CRM1 expression measured after 24 hrs by Western blot analysis
Induction of CRM1 degradation in human HGC-27 cells assessed as reduction in CRM1 expression measured after 24 hrs by Western blot analysis
Inhibition of immobilized HsCRM1-HsRanGTP-HsSPN binding to C-terminal His6-tagged and MBP-fused full length human CRM1 expressed in Escherichia coli SG13009 at 20 nmol incubated for 20 mins by pull-down assay
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on