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Inhibition of USP1 (unknown origin) using Ub-Rho measured after 0.5 to 3 hrs
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibitor Assay from US Patent US11485736: "Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors"
Assay data:106 Active, 121 Activity ≤ 1 µM, 121 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
HTS Assay from US Patent US11161848: "Purinones as ubiquitin-specific protease 1 inhibitors"
Assay data:480 Active, 361 Activity ≤ 1 µM, 530 Tested
Enzymatic Assay from US Patent US11739077: "Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof"
Assay data:22 Active, 21 Activity ≤ 1 µM, 22 Tested
Ubitquin-Rhodamine 110 Assay for USP1 Activity from US Patent US10399980: "Purinones as ubiquitin-specific protease 1 inhibitors"
Assay data:487 Active, 364 Activity ≤ 1 µM, 539 Tested
Inhibition Assay from US Patent US9802904: "Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof"
Assay data:59 Active, 32 Activity ≤ 1 µM, 62 Tested
Ubitquin-Rhodamine 110 Assay for USP1 Activity from US Patent US10189841: "Purinones as ubiquitin-specific protease 1 inhibitors"
Assay data:538 Active, 52 Activity ≤ 1 nM, 538 Activity ≤ 1 µM, 538 Tested
Inhibition of USP1 (unknown origin)
Assay data:13 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of USP1 (unknown origin) at 10 uM relative to control
Assay data:2 Tested
Assay data:1 Tested
Inhibition of His6-tagged human USP1 expressed in insect Sf21 cells coexpressing untagged UAF1 assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine110-glycine using Ubiquitin-Rhodamine110-glycine as substrate by fluorescence based analysis
Assay data:8 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of USP1/UAF1 complex in HEK293T cells assessed as decrease in ability of DNA polymerase eta to bypass UV-induced DNA lesions after 24 hrs by strand specific PCR-based competitive replication and adduct bypass assay
Inhibition of USP1/UAF1 complex in human H596 cells assessed as potentiation of cisplatin-induced cell killing by measuring cisplatin GI50 at 1:4 cisplatin to compound ratio pretreated for 48 hrs followed by addition of fresh growth medium measured after 5 to 10 days by colony forming assay (Rvb = 486 nM)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate preincubated for 30 mins followed by substrate addition by fluorescence-based HTS assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of USP1 (unknown origin) by Ub-Rho110 assay
Inhibition of USP1/UAF1 complex (unknown origin) by Ub-PCNA substrate assay
Inhibition of USP1/UAF1 complex (unknown origin) assessed as reduction in K63-linked diUb cleavage by gel electrophoresis based orthogonal diUb cleavage assay
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