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Agonist activity at human TRPC4 stably expressed in T-REx-293 cells assessed as increase in calcium flux at 10 uM by Fura-2AM dye based fluorescence plate reader assay
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human TRPC4 stably expressed in T-REx-293 cells assessed as increase in calcium flux at 10 uM by Fura-2AM dye based fluorescence plate reader assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TRPC4 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of EA-evoked Ca2+ entry by measuring reduction in intracellular Ca2+ level by Fluo-4 dye based FLIPR assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human TRPC4 channel expressed in HEK293 cells assessed as inhibition of EA-evoked Calcium influx by measuring reduction in intracellular Ca2+ level and measured upto 360 sec by Fluo-4/AM dye based FLIPR assay
Assay data:1 Active, 2 Tested
Antagonist activity at human TRPC4 at <= 30 uM
Potency index, ratio of test compound to englerin A for agonist activity at human TRPC4/TRPC1 expressed in HEK293 Tet cells
Assay data:3 Tested
Agonist activity at human TRPC4/TRPC1 expressed in HEK293 Tet cells assessed as increase in intracellular calcium level at 1 uM measured at 5 secs interval for 300 secs in presence of TRPC4/5 antagonist Pico145 by Fura-2AM dye based fluorescence assay
Assay data:5 Tested
Agonist activity at human TRPC4/TRPC1 expressed in HEK293 Tet cells assessed as increase in intracellular calcium level at 0.1 uM measured at 5 secs interval for 300 secs by Fura-2AM dye based fluorescence assay
Assay data:1 Active, 5 Tested
Agonist activity at human TRPC4/TRPC1 expressed in HEK293 Tet cells assessed as increase in intracellular calcium level at 1 uM measured at 5 secs interval for 300 secs by Fura-2AM dye based fluorescence assay
Assay data:5 Active, 5 Tested
Inhibition of Englerin-activated human TRPC4 channel expressed in HEK293 cells by Q-patch clamp assay
Inhibition of TRPC4 (unknown origin) expressed in HEK293 cells assessed as reduction in englerin A-induced current at 5 uM measured every 10 secs by outside-out patches based electrophysiology assay relative to control
Inhibition of human TRPC4 expressed in human T-REx-293 cells coexpressing M1 receptor assessed as reduction in calcium influx by Fluo-4AM dye based assay
Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in sphingosine-1-phosphate-induced current at +100 mV by patch clamp assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in sphingosine-1-phosphate-induced current at -100 mV by patch clamp assay
Inhibition of human TRPC4/human TRPC1 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fluo-4AM dye based fluorescence assay
Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fluo-4AM dye based fluorescence assay
Antagonist activity at TRPC4/TRPC1 in human A498 cells assessed as reduction in englerin A-induced calcium entry preincubated for 30 mins followed by englerin A addition by fluorescence method
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of TRPC4 (unknown origin)
Human TRPC4 (Transient Receptor Potential channels)
Assay data:4 Active, 4 Tested
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