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Binding affinity to TIAM1 PH-domain (unknown origin) at 0.01 to 50 uM by SPR spectroscopy
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of Rac1-Tiam1 protein-protein interaction in human A617 cells assessed as reduction in intracellular Rac1-GTP levels at 1 to 10 uM after 4 hrs by G-LISA assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Rac1-Tiam1 protein-protein interaction in human A617 cells assessed as reduction in intracellular Rac1-GTP levels at 10 uM after 4 hrs by G-LISA assay relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Inhibition of Rac1-Tiam1 interaction in human smooth muscle cells assessed as reduction of PDGF-BB stimulated GTP bound Rac1 level preincubated for 4 hrs followed by PDGF-BB stimulation measured after 2 mins by G-LISA assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Rac1-Tiam1 interaction in human smooth muscle cells assessed as reduction of PDGF-BB stimulated GTP bound Rac1 level at 10 uM preincubated for 4 hrs followed by PDGF-BB stimulation measured after 2 mins by G-LISA assay relative to control
Assay data:5 Active, 6 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
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