BioAssay by Target (List) for Gene (Select 6850) - PubChem BioAssay - NCBI

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Select item 19197581.

SYK Inhibition from US Patent US20230295171: "FUSED HETEROAROMATIC PYRROLIDINONES"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase SYK; ...
Total:: 1

Assay data:124 Active, 5 Activity ≤ 1 nM, 106 Activity ≤ 1 µM, 128 Tested

AID:: 1919758

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19190812.

High Throughput Syk Biochemical Assay from US Patent US11517570: "Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase SYK; ...
Total:: 1

Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested

AID:: 1919081

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19154143.

Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1915414

Summary Related BioAssays by Target

Select item 19154134.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000232b SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1915413

Summary Related BioAssays by Target

Select item 19139745.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1913974

Summary Related BioAssays by Target

Select item 19139166.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000305b SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1913916

Summary Related BioAssays by Target

Select item 19134617.

Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000153b SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1913461

Summary Related BioAssays by Target

Select item 19131838.

Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000714a SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913183

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131689.

Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000704a SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Active, 1 Tested

AID:: 1913168

Summary Compounds, Active Related BioAssays by Target

Select item 191292910.

Affinity On-target Cellular interaction (Cellular human mast cell degranulation assay) EUB0000714a SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912929

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191275511.

Affinity Phenotypic Cellular interaction (Cellular human mast cell degranulation assay) EUB0000714a SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912755

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191274712.

Affinity Phenotypic Cellular interaction (Cellular human mast cell degranulation assay) EUB0000704a SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1912747

Summary Related BioAssays by Target

Select item 190242013.

Inhibition of SYK (unknown origin) at 50 nM by Z'LYTE screening method relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:12 Tested

AID:: 1902420

Summary PubMed Citation Related BioAssays by Target

Select item 190151614.

Inhibition of recombinant full-length human Syk at 1 uM assessed as residual activity at 1 uM using poly(Glu, Tyr) 4:1 as substrate measured after 40 mins in presence of [gamma33P]ATP by radiometric scintillation counting method relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1901516

Summary PubMed Citation Related BioAssays by Target

Select item 189830015.

Inhibition of human SYK assessed as residual activity at 30 uM relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1898300

Summary PubMed Citation Related BioAssays by Target

Select item 189403216.

Competitive inhibition of SYK (unknown origin) assessed as inhibition constant in the presence of ATP at Km concentration

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894032

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186603917.

Inhibition of SYK (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1866039

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186558618.

Inhibition of human full length recombinant N-terminal GST-tagged SYK expressed in baculovirus expression system at 250 nM by Z'-lyte assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1865586

Summary PubMed Citation Related BioAssays by Target

Select item 186555519.

Inhibition of SYK (unknown origin) assessed as reduction of IgM-stimulated ERK phosphorylation by Cell-based assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1865555

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185564020.

Inhibition of SYK (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1855640

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (283)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (68)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (250)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (349)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (63)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (674)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (68)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (628)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (111)
BioAssays deposited by other experimentalists

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