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Potency index, ratio of IC50 of pargyline to IC50 for test compound for inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in NADH oxidation incubated for 1 hr
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 10 uM in presence of proline by IncuCyte imaging system based assay relative to control
Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at 10 uM in presence of proline by IncuCyte imaging system based assay relative to control
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 10 uM in absence of proline by IncuCyte imaging system based assay relative to control
Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at 10 uM in absence of proline by IncuCyte imaging system based assay relative to control
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline M+5 content at 5 uM incubated for 24 hrs in presence of [U-13C]-glutamine by LC-MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content by LC-MS analysis relative to control
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content at 1 uM by LC-MS analysis relative to control
Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content at 100 uM by LC-MS analysis relative to control
Inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in NADH oxidation incubated for 1 hr
Assay data:3 Active, 61 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to PYCR1 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
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