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Inhibition of PTPalpha (unknown origin)
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US9522881: "Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of His-tagged PTPalpha (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for 5 to 10 mins by microplate reader based spectrophotometric analysis
Assay data:9 Tested
Inhibition of PTPRA (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of PTPalpha (unknown origin) using pNPP as substrate at 200 uM after 5 mins by spectrophotometry
Inhibition of PTP-alpha (residue 203 to 503) (unknown origin) using para-nitrophenylphosphate as substrate at 20 uM for 60 mins by fluorescence analysis
Inhibition of phosphatase activity of human PTPalpha using pNPP as a substrate after 10 mins by spectrophotometer analysis
Assay data:4 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Binding affinity to PTPalpha in human MCF7 cells by SDS-PAGE based pull-down assay
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Inhibition of recombinant PTPalpha (unknown origin) using pNPP as substrate at 100 uM by spectrophotometric analysis
Assay data:2 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Inhibition of PTPalpha (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis
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