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Induction of eIF2alpha phosphorylation (unknown origin) assessed as fold increase in ATF-4 stimulation at 2.5 uM by dual luciferase reporter assay
Assay data:4 Tested
SummaryRelated BioAssays by Target
Induction of eIF2alpha phosphorylation (unknown origin) assessed as fold increase in ATF-4 stimulation at 5 uM by dual luciferase reporter assay
Assay data:1 Tested
Induction of eIF2alpha phosphorylation (unknown origin) assessed as fold increase in ATF-4 stimulation at 80 uM by dual luciferase reporter assay
Assay data:5 Tested
Induction of eIF2alpha phosphorylation (unknown origin) assessed as fold increase in ATF-4 stimulation at 20 uM by dual luciferase reporter assay
Assay data:8 Tested
Induction of eIF2alpha phosphorylation (unknown origin) assessed as fold increase in ATF-4 stimulation at 40 uM by dual luciferase reporter assay
Assay data:11 Tested
Induction of eIF2alpha phosphorylation (unknown origin) assessed as fold increase in ATF-4 stimulation at 10 uM by dual luciferase reporter assay
Assay data:7 Tested
Induction of eIF2alpha phosphorylation in human CRL-2813 cells assessed as fold increase in CHOP expression incubated for 6 hrs by RT-PCR analysis
Assay data:6 Tested
Inhibition of GST tagged human PKR incubated for 10 mins in presence of ATP by Kinase Glo luminescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PKR (unknown origin)
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000310b EIF2AK2
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000316c EIF2AK2
Binding affinity to wild type EIF2AK2 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PKR (unknown origin) assessed as fold change
PRKR DiscoveRx kinase panel
PKR(h) Kinase panel
Inhibition of EIF2AK2 (unknown origin) assessed as residual activity at 5 uM
Inhibition of EIF2AK2 (unknown origin) at 1000 nM relative to control
PKR KinaseGlo Assay from US Patent US10669265: "Pyridyl benzothiophenes as kinase inhibitors"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
KinaseGlo Assay from US Patent US10633373: "Pyridyl benzothiophenes as kinase inhibitors"
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