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hDPP8 Inhibition Assay from US Patent US20230312550: "N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES"
Assay data:14 Active, 2 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Inhibition Assay from US Patent US11583516: "Dash inhibitors, and uses related thereto"
Assay data:13 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
EnPlex (purified enzyme activity assay) from US Patent US11559537: "Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists"
Assay data:49 Active, 10 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 50 Tested
In Vitro Inhibition Assay from US Patent US11096924: "Combination therapies using immuno-dash inhibitors and PGE2 antagonists"
Assay data:34 Active, 10 Activity ≤ 1 µM, 49 Tested
Kinetics Assays from Article 10.1074/jbc.M113.489179: "The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9."
Assay data:6 Active, 4 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
DPP-IV Inhibition Screening Assay from Article 10.1111/cbdd.12663: "Synthesis, Biological Evaluation, and Molecular Docking of (R)-2-((8-(3-aminopiperidin-1-yl)-3-methyl-7-(3-methylbut-2-en-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)methyl)benzonitrile as Dipeptidyl Peptidase IV Inhibitors."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
DPP-VIII Assay from US Patent US8470836: "Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent"
Assay data:6 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Dipeptidyl Peptidase Inhibition Assay from Article 10.1016/j.bmcl.2007.02.066: "4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV."
Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested
DPP Inhibition Assay from Article 10.1021/jm070104l: "Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV."
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Dipeptidyl Peptidase Inhibition Assay from Article 10.1016/j.bmcl.2007.01.039: "Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes."
Assay data:30 Active, 30 Activity ≤ 1 µM, 30 Tested
DPP Inhibition Assay from Article 10.1021/jm061436d: "Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors."
Assay data:24 Active, 22 Activity ≤ 1 µM, 24 Tested
DPP Inhibition Assay from Article 10.1016/j.bmcl.2007.01.026: "Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit."
Assay data:27 Active, 24 Activity ≤ 1 µM, 28 Tested
DPP Inhibition Assay from Article 10.1016/j.bmcl.2006.09.024: "Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors."
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
Dipeptidyl Peptidase Inhibition Assay from Article 10.1016/j.bmcl.2006.09.099: "(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes."
Assay data:15 Active, 3 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 16 Tested
DPP Inhibition Assay from Article 10.1021/jm060955d: "Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes."
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
DPPIV Inhibition Assay from Article 10.1021/jm060777o: "Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]-4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes."
Assay data:23 Active, 2 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 25 Tested
Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2004.11.023: "Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8."
Assay data:14 Active, 11 Activity ≤ 1 µM, 18 Tested
Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2006.03.037: "Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors."
Assay data:18 Active, 15 Activity ≤ 1 µM, 18 Tested
Dipeptidyl Peptidase Inhibition Assay from Article 10.1016/j.bmcl.2005.03.012: "Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole."
Assay data:33 Active, 33 Activity ≤ 1 µM, 33 Tested
Dipeptidyl Peptidase Inhibition Assay from Article 10.1021/jm0507781: "2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV."
Assay data:29 Active, 25 Activity ≤ 1 µM, 29 Tested
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