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Inhibition of PI4KB catalytic domain (unknown origin) assessed as enzyme residual activity incubated for 60 mins using ATP as substrate by ATP-Glo luminescent assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000707a PI4KB
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Lipid kinase panel (AstraZeneca)) EUB0000631a PI4KB
Inhibition of PI4KB (unknown origin) at 1 uM in presence of ATP by Adapta assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PI4KB (PI4K beta) (unknown origin) at 0.1 uM relative to control
Inhibition of PI4Kbeta (unknown origin)
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PI4KIIIbeta (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
PIK4CB DiscoveRx kinase panel
Inhibition of PI4KB expressed in human PBMCs measured at 10 uM by KiNativ profiling analysis relative to control
Binding affinity to human PIK4CB (M1/M828) WT expressed in mammalian system assessed as dissociation constant measured at 1 uM by DiscoveRx KINOMEscan assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human PIK4CB (M1/M828) WT expressed in mammalian system assessed as remaining activity measured at 1 uM by DiscoveRx KINOMEscan assay relative to control
Inhibition of PI4KB (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Kinase Activity Assay from US Patent US11091472: "PI-kinase inhibitors with anti-infective activity"
Assay data:102 Active, 54 Activity ≤ 1 µM, 113 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Invitrogen SelectScreen Enzymatic Assay from Article 10.1021/acschembio.6b00250: "Discovery of a Highly Selective STK16 Kinase Inhibitor."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Kinase Glo Luminescent Kinase Assay from US Patent US9862711: "Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Kinase Glo Luminescent Kinase Assay (Kglo) for PI 3-Kinase Alpha (A), PI 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D) from US Patent US10112926: "Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors"
Assay data:226 Active, 186 Activity ≤ 1 µM, 226 Tested
KinomeScan assay: inhibition of PIK4CB
Assay data:108 Tested
PI4KB (PI4K beta) Kinase screen
PI4KB Invitrogen selectivity data (BI)
PI4KB Invitrogen Lab (UK) kinase screen (BI)
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