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Inhibition of pendrin in human bronchial CFBE assessed as increase in airway surface liquid depth at 25 uM by rhodamine B-dextran fluorescence based confocal microscopy (Rvb = -16 um)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of pendrin in human bronchial epithelial cells assessed as increase in airway surface liquid depth at 25 uM by rhodamine B-dextran fluorescence based confocal microscopy (Rvb = -16 um)
Inhibition of pendrin in IL13-stimulated human CFBE assessed as reduction in gluconate gradient-induced intracellular alkalization at 25 uM
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of pendrin in IL13-stimulated human bronchial epithelial cells assessed as reduction in gluconate gradient-induced intracellular alkalization at 25 uM
Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17HCO3(-) exchange by measuring reduction in cytoplasmic alkalinization exchange at 2.5 uM by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17HCO3(-) exchange by measuring reduction in cytoplasmic alkalinization exchange at 25 uM by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Assay data:2 Active, 2 Tested
Time dependent inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Assay data:2 Tested
Reversible inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange incubated for 10 mins measured after wash out by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17NO3(-) exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated Cl(-)/r exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17F exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated anion exchange at 25 uM incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Assay data:22 Tested
Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated anion exchange at 100 uM incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control
Inhibition of human PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mins by fluorescence based assay
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as translocation of mutant protein from cytoplasm to plasma membrane at 1 to 10 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis
Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as intracellular localization of mutant protein in plasma membrane at 10 mM incubated for 12 hrs followed by compound washout measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis
Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as intracellular localization of mutant protein in plasma membrane at 0.1 mM incubated for 12 hrs followed by compound washout measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis
Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as fluorescence intensity ratio of plasma membrane to cytoplasm at 0.1 mM measured after 12 hrs by DAPI staining based immunofluorescence microscopic method
SummaryPubMed CitationRelated BioAssays by Target
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