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Inhibitory Assay from US Patent US10793582: "Bicyclic heterocyclic compound"
Assay data:84 Active, 79 Activity ≤ 1 µM, 84 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Spectra Assay from US Patent US8933095: "KAT II inhibitors"
Assay data:29 Active, 28 Activity ≤ 1 µM, 29 Tested
Inhibition Spectra Assay from US Patent US8598200: "KAT II inhibitors"
KAT-II inhibitory assay from US Patent US10065972: "Bicyclic or tricyclic heterocyclic compound"
Assay data:187 Active, 170 Activity ≤ 1 µM, 189 Tested
Binding affinity to recombinant human KAT2 assessed as change in temperature by thermal shift assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Reversible inhibition of recombinant human KAT2 assessed as reduction in kynurenic acid formation at 50 uM using L-kynurenine as substrate by fluorescence assay relative to control
Assay data:3 Tested
Reversible inhibition of recombinant human KAT2 assessed as reduction in kynurenic acid formation using L-kynurenine as substrate by fluorescence assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of KAT2 (unknown origin)
Inhibition of KAT2 (unknown origin) at 100 uM
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Ratio of Kinact to Ki for KAT2 (unknown origin)
Assay data:5 Tested
SummaryRelated BioAssays by Target
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysis
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
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