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Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b SUV420H1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel) EUB0000196bCl SUV420H1
Selectivity interaction (HMT panel) EUB0000194b SUV420H1
Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b SUV420H1
Affinity Biochemical interaction (Scintillation proximity assay (SPA)) EUB0000193b SUV420H1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Western Blot (decrease in di-methylation of H4K20me in U20S cells)) EUB0000193b SUV420H1
Inhibition of human recombinant N-terminal GST-tagged SUV420H1-tv2 (2 to 393 residues) expressed in baculovirus infected insect cell at 50 uM using histone as substrate by scintillation/filter plate assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant N-terminal GST-tagged SUV420H1-tv2 (2 to 393 residues) expressed in baculovirus infected insect cell at 10 uM using histone as substrate by scintillation/filter plate assay
Inhibition of SUV420H1 (unknown origin) at 1 to 10 uM
Assay data:2 Tested
Scintillation Proximity Assay (SPA) from Article 10.1038/nchembio.2282: "The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity."
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SUV4-20H1 (unknown origin) at 10 uM using SAM as substrate measured up to 960 mins by AlphaScreen microplate reader assay relative to control
Inhibition of recombinant human N-terminal GST-tagged SUV420H1 (2 to 393 residues ) expressed in baculovirus infected Sf9 cells using core histone as substrate at 10 uM by radiometric HotSpot assay relative to control
Inhibition of SUV420H1 (unknown origin) using biotin-labeled histone substrate assessed as residual activity at 50 uM in presence of [3H-Me]SAM by scintillation proximity assay relative to control
Assay data:24 Tested
Inhibition of human SUV420H1 up to 50 uM using Biot-H4K20me1 as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay
Inhibition of SUV420H1 in human MCF7 cells assessed as decrease in H4K20me3 level up to 50 uM measured after 2 days by immunoblot analysis
Inhibition of SUV420H1 (unknown origin) at 1 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SUV420H1 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 10 uM incubated for 1 hr by scintillation proximity assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of SUV420H1 (unknown origin) at 10 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay
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