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Inhibition of human TRAAK expressed in Xenopus laevis oocytes assessed as inhibition of channel current at 10 uM at +40mV holding potential by two-electrode voltage clamp assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human TRAAK at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method
Activation of K2P4.1 (unknown origin) at 30 uM by manual patch clamp method relative to control
Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay relative to control
SummaryRelated BioAssays by Target
Binding affinity to purified TRAAK (unknown origin) at 1 to 200 uM following exposure to 254 nm UV light for 30 secs by SDS-PAGE and streptavidin-HRP detection based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential at 100 uM by two-electrode voltage clamp assay relative to control
Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay
Binding affinity to K2P4.1 (unknown origin) assessed as induction of protein cross linking and labelling at 1 to 200 uM following 254 nm UV light irradiation for 30 secs by SDS-PAGE analysis
Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 100 uM at -80 mV holding potential by two-electrode voltage clamp assay
Activation of recombinant human TRAAK D227Y mutant expressed in HEK293T cells assessed as increase in K+ current amplitude at 10 uM by whole cell voltage clamp electrophysiological analysis relative to control
Activation of recombinant human TRAAK expressed in HEK293T cells assessed as increase in K+ current amplitude at 10 uM by whole cell voltage clamp electrophysiological analysis relative to control
Activation of recombinant human TRAAK expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clamp electrophysiological analysis
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Agonist activity at TRAAK (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 100 uM measured at +60 mV by whole-cell patch clamp method relative to control
Agonist activity at TRAAK (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 10 uM measured at +60 mV by whole-cell patch clamp method relative to control
Agonist activity at TRAAK (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 20 uM measured at +60 mV by whole-cell patch clamp method relative to control
Human K2P4.1 (Two P domain potassium channels)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of of human TRAAK expressed in HEK293 cells assessed as reduction in channel currents at 10 uM
Activation of TRAAK (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents
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