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Inhibition of iNOS (unknown origin)
Assay data:5 Tested
SummaryRelated BioAssays by Target
Inhibition of human iNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assay
Assay data:6 Active, 1 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant iNOS (unknown origin) assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate at 10 uM by Enzymatic NOS activity assay
Assay data:10 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Time dependent inhibition of human iNOS at 50 to 800 nM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human iNOS assessed as dissociation constant by surface plasmon resonance assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human iNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Nitric Oxide Suppression Assay from US Patent US11059792: "Imidazolyl tricyclic enones as antioxidant inflammation modulators"
Assay data:27 Active, 27 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US9090589: "Specific nNOS inhibitors for the therapy and prevention of human melanoma"
Assay data:8 Active, 8 Activity ≤ 1 µM, 9 Tested
Spectral Binding Assay from Article 10.1021/bi500561h: "The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Enzyme Assay from US Patent US8618286: "Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity"
Assay data:4 Active, 29 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assay from US Patent US8586620: "Substituted indole compounds having NOS inhibitory activity"
Assay data:49 Active, 18 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Assay from Article 10.1021/bi1013479: "Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase ."
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
NOS Enzyme Inhibition Assay from Article 10.1038/nchembio.115: "Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase."
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
Cell-Based NOS Transient Transfection Assay from Article 10.1021/jm900173b: "Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models."
Assay data:36 Active, 31 Activity ≤ 1 µM, 41 Tested
Inhibition Assay from US Patent US9951014: "Mammalian and bacterial nitric oxide synthase inhibitors"
Assay data:35 Active, 32 Activity ≤ 1 µM, 35 Tested
Enzyme Assay from US Patent US9783500: "2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition"
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Inhibition Assay from US Patent US9732037: "2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors"
Assay data:21 Active, 20 Activity ≤ 1 µM, 21 Tested
Pyridine Analogs Inhibit NO Production from US Patent US10189791: "Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole"
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Caco-2 Assay from US Patent US9878996: "2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase"
Assay data:13 Active, 9 Activity ≤ 1 µM, 14 Tested
Nitric Oxide Synthase, Inducible (iNOS) Eurofins-Panlabs enzyme assay
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