BioAssay by Target (List) for Gene (Select 4217) - PubChem BioAssay - NCBI

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Select item 19192321.

HTRF KinEASE Assay from US Patent US11560368: "Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof"

Source:: BindingDB

Protein Targets:: Mitogen-activated protein kinase kinase kinase 5; ...
Total:: 1

Assay data:65 Active, 1 Activity ≤ 1 nM, 70 Activity ≤ 1 µM, 70 Tested

AID:: 1919232

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19141232.

Selectivity interaction (SelectScreen (Invitrogen)) EUB0000715a MAP3K5

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914123

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138863.

Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000321b MAP3K5

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1913886

Summary Related BioAssays by Target

Select item 19138854.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000321b MAP3K5

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1913885

Summary Related BioAssays by Target

Select item 19134585.

Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000153b MAP3K5

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1913458

Summary Related BioAssays by Target

Select item 19133926.

Selectivity interaction (Upstate Kinase Profiler service (Millipore)) EUB0000056c MAP3K5

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913392

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19125507.

Thermal Shift Assay. Domain: start/stop: R659-L951

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:27 Tested

AID:: 1912550

Summary Related BioAssays by Target

Select item 19015458.

Inhibition of recombinant human ASK1 (649 to 946 residues) assessed as residual activity at 1 uM using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P]ATP by radiometric scintillation counting method

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1901545

Summary PubMed Citation Related BioAssays by Target

Select item 18940419.

Inhibition of ASK1 (unknown origin) in presence of ATP

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894041

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189404010.

Inhibition of ASK1 (unknown origin)

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894040

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186044511.

Inhibition of ASK1 (unknown origin) at 0.5 uM relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1860445

Summary PubMed Citation Related BioAssays by Target

Select item 183561012.

ASK1 DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1835610

Summary Related BioAssays by Target

Select item 183528413.

MAP3K5 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1835284

Summary Related BioAssays by Target

Select item 183486614.

ASK1(h) Kinase panel

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1834866

Summary Related BioAssays by Target

Select item 183403015.

Inhibition of ASK1 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1834030

Summary PubMed Citation Related BioAssays by Target

Select item 181624616.

Inhibition of human recombinant ASK1 assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1816246

Summary PubMed Citation Related BioAssays by Target

Select item 181072117.

Inhibition of ASK1 (unknown origin) at 1000 nM relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 5

Assay data:1 Tested

AID:: 1810721

Summary PubMed Citation Related BioAssays by Target

Select item 180688418.

HTRF KinEASE Assay from US Patent US11466033: "Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors"

Source:: BindingDB

Protein Targets:: Mitogen-activated protein kinase kinase kinase 5; ...
Total:: 1

Assay data:19 Active, 21 Activity ≤ 1 µM, 21 Tested

AID:: 1806884

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180679219.

Kinase Assay from US Patent US11434249: "ASK1 inhibitor compounds and uses thereof"

Source:: BindingDB

Protein Targets:: Mitogen-activated protein kinase kinase kinase 5; ...
Total:: 1

Assay data:12 Active, 11 Activity ≤ 1 µM, 12 Tested

AID:: 1806792

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180657420.

HTRF KinEASE Assay from US Patent US11345699: "Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof"

Source:: BindingDB

Protein Targets:: Mitogen-activated protein kinase kinase kinase 5; ...
Total:: 1

Assay data:151 Active, 152 Activity ≤ 1 µM, 152 Tested

AID:: 1806574

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

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Target

Proteins (8)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (112)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (21)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (93)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (118)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (42)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (289)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (251)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (77)
BioAssays deposited by other experimentalists

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