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Human LTC4S Enzymatic Assay from US Patent US11708366: "Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof"
Assay data:13 Active, 34 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of recombinant LTC4S (unknown origin) expressed in COS cells
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant LTC4S expressed in HEK293 cell microsomal fraction preincubated for 10 mins followed by LTA4-methyl ester addition and measured after 10 mins by UPLC-MS/MS analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In Vitro hLTC4 Synthase Enzyme Assay (Test B) from US Patent US20160326143: "Compounds and uses "
Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro hLTC4 Synthase Enzyme Assay (Test A) from US Patent US20160326143: "Compounds and uses "
Assay data:60 Active, 57 Activity ≤ 1 µM, 60 Tested
In Vitro hLTC4 Synthase Enzyme Assay from US Patent US9657001: "Compounds and uses"
Assay data:65 Active, 4 Activity ≤ 1 nM, 62 Activity ≤ 1 µM, 65 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Leukotriene LTC4 Synthase Eurofins-Panlabs enzyme assay
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant human N-terminal His6-tagged LTC4S expressed in in Pichia pastoris X33 assessed as inhibition of EXC4 formation using EXA4 as substrate preincubated for 10 mins followed by substrate addition and measured after 1 min by EIA
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of LTC4S in asthmatic human whole blood assessed as inhibition of calcium ionophore A23187 stimulated cysteinyl leukotrienes production preincuabted for 30 mins followed by calcium ionophore stimulation and measured after 10 mins by LC-MS analysis
Assay data:3 Active, 3 Tested
Inhibition of LTC4S in healthy human whole blood assessed as inhibition of calcium ionophore A23187 stimulated cysteinyl leukotrienes production preincuabted for 30 mins followed by calcium ionophore stimulation and measured after 10 mins by LC-MS analysis
Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as unbound drug concentration required for inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulation and measured after 20 mins by LC-MS/MS analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulation and measured after 20 mins by LC-MS/MS analysis
Assay data:28 Active, 27 Activity ≤ 1 µM, 32 Tested
Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by LC-MS/MS analysis
Assay data:34 Active, 11 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 34 Tested
Inhibition of LTC4 synthase (unknown origin)
Inhibition of human LTC4 synthase expressed in HEK293 cell microsomes preincubated for 10 mins followed by LTA4-methyl ester addition and measured after 10 mins by UPLC-MS/MS analysis
Assay data:1 Active, 2 Tested
Inhibition of LTC4 synthase in LPS/fMLP-stimulated human monocytes assessed as decrease in cys-LT formation pre-incubated with LPS for 30 mins and later stimulated with fMLP for 10 mins by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Human Leukotriene C4 synthase (Leukotriene and lipoxin metabolism)
Inhibition of recombinant human LTC4 synthase expressed in Pichia pastoris using LTA4 as substrate preincubated for 10 mins followed by substrate addition measured after 1 min by HTRF method
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant human LTC4 synthase expressed in Pichia pastoris using LTA4 as substrate preincubated for 10 mins followed by substrate addition measured after 5 mins by HTRF method
Assay data:41 Active, 41 Activity ≤ 1 µM, 41 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
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