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Biological Assay from US Patent US20230348442: "GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES"
Assay data:176 Active, 169 Activity ≤ 1 µM, 176 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Evaluation of Compound Inhibitory Activity (IC50) from US Patent US20230295182: "SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES"
Assay data:115 Active, 112 Activity ≤ 1 µM, 115 Tested
Antagonist activity against human US7 patient-derived BCP-ALL cells assessed as inhibition of galectin-1-mediated cell-cell cluster formation at 500 uM incubated for 2 hrs by phase contrast microscopy
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity against human TXL2 patient-derived BCP-ALL cells assessed as inhibition of galectin-1-mediated cell-cell cluster formation at 500 uM incubated for 2 hrs by phase contrast microscopy
Binding affinity to human galectin-1 by fluorescence polarization analysis
Binding affinity to human galectin-1 using 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-y1]-3'.(3,5-dimethoxy-benzamido)-1,1'-sulfanediyl-di-beta-D-galactopyranoside as fluorescent probe by fluorescence polarization analysis
Assay data:5 Tested
Inhibition of Alexa-Fluor-488 conjugated galectin-1 binding to human osteoarthritic cartilage at 4 mM of sugar preincubated for 1 hr followed by incubation with tissue material for overnight by 2-colour fluorescence microsocopy
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of His-tagged recombinant human Gal-1 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescence based assay
Assay data:8 Active, 9 Tested
Inhibition in human Gal-1
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
fluorescence anisotropy assay from US Patent US11046725: "Galactoside inhibitor of galectins"
Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested
Fluorescence Anisotropy Assay from US Patent US10988502: "Alpha-D-galactoside inhibitors of galectins"
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
Fluorescence Anisotropy Assay from US Patent US10889610: "Alpha-D-galactoside inhibitors of galectins"
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Evaluation of Kd Values from US Patent US10800804: "Hybrid galactoside inhibitor of galectins"
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:9 Active, 2 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
fluorescence anisotropy assay from US Patent US10730902: "1,1 ′-sulfanediyl-di-beta-D-galactopyranosides as inhibitors of galectins"
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Fluorescence Polarization Assay from Article 10.1002/cbic.201600673: "Lactosamine-Based Derivatives as Tools to Delineate the Biological Functions of Galectins: Application to Skin Tissue Repair."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Fluorescence Polarization-Based Assay from US Patent US8703720: "Galactoside inhibitors of galectins"
Assay data:7 Active, 6 Activity ≤ 1 µM, 9 Tested
Fluorescence Polarization Assay from Article 10.1016/j.bmc.2005.09.050: "Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors."
Assay data:14 Tested
Binding affinity to human galactin-1 assessed as dissociation constant by competitive fluorescence polarization assay
Assay data:2 Tested
Binding affinity to human Gal-1 assessed as Gibbs free energy change by isothermal titration calorimetry
Assay data:6 Tested
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