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Inhibition of IL-6 (unknown origin) relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Interleukin 6 Induction Assay from US Patent US10981914: "Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor"
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
IL-6 Induction assay from US Patent US10919895: "Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
Interleukin 6 Induction Assay from US Patent US10508115: "Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor"
Assay data:54 Active, 54 Activity ≤ 1 µM, 54 Tested
Interleukin 6 Induction Assay from US Patent US10487084: "Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Interleukin 6 Induction Assay from US Patent US10457681: "Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor"
IL-6 Production Inhibitory Action Evaluation Test from US Patent US10435379: "[4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof"
Assay data:9 Active, 1 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Fluorescence Polarization Ligand Binding Assay from US Patent US8901310: "Tricyclic compounds, compositions, and methods"
Assay data:14 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
IL-6 Production Inhibitory Action Evaluation from US Patent US10189796: "[4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof"
cytomteric bead array (CBA) assay from US Patent US9694015: "Methods for the treatment of locally advanced breast cancer"
Assay data:9 Active, 5 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 10 Tested
Fibroblast IL-6 assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
In vitro inhibition of IL-6 in Lipopolysaccharide-stimulated human whole blood
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of IL6 (unknown origin)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of IL-6 signaling pathway in human HepG2 cells transfected with p-STAT3-Luc assessed as reduction in IL-6 induced STAT3 phosphorylation preincubated for 1 hr followed by IL-6 induction measured after 10 mins by immunoblot analysis
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of IL-6 signaling pathway in human HepG2 cells transfected with p-STAT3-Luc assessed as reduction in IL-6 induced STAT3 phosphorylation at 20 ug/ml preincubated for 1 hr followed by IL-6 induction measured after 10 mins by immunoblot analysis
Assay data:16 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
TLR-pathway-human_P3C ligand_TNF readout
Assay data:143 Active, 756 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
TLR-pathway-human_R848 ligand_TNF readout
Assay data:134 Active, 756 Tested
TLR-pathway-human_FLG ligand_TNF readout
Assay data:142 Active, 756 Tested
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