BioAssay by Target (List) for Gene (Select 3350) - PubChem BioAssay - NCBI

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Select item 19194231.

Radioligand Binding Assay from US Patent US11642336: "5-HT2A agonists for use in treatment of depression"

Source:: BindingDB

Protein Targets:: 5-hydroxytryptamine receptor 1A; ...
Total:: 19

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1919423

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19178052.

Displacement of [3H]8-OH-DAPT from 5-HT1A receptor in human HEK293 cells measured after 60 mins by scintillation counting method

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1917805

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19177993.

Displacement of [3H]8-OH-DAPT from 5-HT1A receptor in human HEK293 cells at 1 uM measured after 60 mins by scintillation counting method relative to control

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:18 Tested

AID:: 1917799

Summary PubMed Citation Related BioAssays by Target

Select item 19170754.

Displacement of [3H]-Raclopride from human 5-HT1AR expressed in HEK293 cells by radioligand binding assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:5 Active, 1 Activity ≤ 1 µM, 6 Tested

AID:: 1917075

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19164625.

Binding affinity to 5-HT1A (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1916462

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19164566.

Binding affinity to human 5-HT1A assessed as inhibition constant

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1916456

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19154017.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000302b HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Tested

AID:: 1915401

Summary Related BioAssays by Target

Select item 19151158.

Selectivity interaction (CEREP ExpressProfile selectivity/specificity profile (human recombinant receptors)) EUB0000213bCl HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Tested

AID:: 1915115

Summary Related BioAssays by Target

Select item 19150759.

Selectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915075

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191502710.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000346a HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915027

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191496611.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914966

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191457512.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914575

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191455413.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Active, 1 Tested

AID:: 1914554

Summary Compounds, Active Related BioAssays by Target

Select item 191446014.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000735a HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Tested

AID:: 1914460

Summary Related BioAssays by Target

Select item 191400815.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a HTR1A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Active, 1 Tested

AID:: 1914008

Summary Compounds, Active Related BioAssays by Target

Select item 191238416.

Binding affinity to 5-HT1A receptor (unknown origin) at 10000 nM by radioligand displacement assay relative to control

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Tested

AID:: 1912384

Summary PubMed Citation Related BioAssays by Target

Select item 191095317.

Inhibition of serotonin 5-HT1A receptor (unknown origin) at 10 uM relative to control

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Tested

AID:: 1910953

Summary PubMed Citation Related BioAssays by Target

Select item 190860718.

Agonist activity at human 5HT1A receptor expressed in HEK293 cells

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:8 Tested

AID:: 1908607

Summary PubMed Citation Related BioAssays by Target

Select item 190758519.

Antagonist activity at human 5-HT1A receptor at 10 uM relative to control

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Tested

AID:: 1907585

Summary PubMed Citation Related BioAssays by Target

Select item 190756220.

Agonist activity at human 5-HT1A receptor at 10 uM relative to control

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:1 Tested

AID:: 1907562

Summary PubMed Citation Related BioAssays by Target

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Proteins (31)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (843)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (219)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (770)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
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Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
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Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (1,531)
BioAssays extracted from the literature
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BioAssays deposited by the NIH Molecular Libraries Program
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