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Enzymatic Activity Assay from US Patent US20230286970: "NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS"
Assay data:417 Active, 417 Activity ≤ 1 µM, 417 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
HDACs 1, 2, and 3 Enzymatic Inhibitions from US Patent US11672788: "Histone deacetylase inhibitors for immunomodulation in tumor microenvironment"
Assay data:11 Active, 3 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 13 Tested
Inhibition of Histone Deacetylase Enzymatic Activity Assay from US Patent US11572368: "Inhibitors of histone deacetylase"
Assay data:149 Active, 122 Activity ≤ 1 µM, 171 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
HDAC Enzyme Assay from US Patent US11542242: "Substituted piperazines as selective HDAC1,2 inhibitors"
Assay data:52 Active, 57 Activity ≤ 1 µM, 57 Tested
Electrophoretic Mobility Shift Assay from US Patent US11535607: "Isoindolines as HDAC inhibitors"
Assay data:1 Active, 2 Activity ≤ 1 µM, 2 Tested
Method of Inhibiting HDAC8 from US Patent US11505523: "HDAC8 inhibitors for treating cancer"
Assay data:19 Active, 18 Activity ≤ 1 µM, 19 Tested
Inhibition of HDAC2 (unknown origin) using fluorometric substrate by fluorogenic assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HDAC2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human full length FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 cells using BML-KI104 as substrate preincubated for 3 hrs followed by substrate addition measured after 60 mins by modified FLUOR DE LYS assay
Assay data:54 Active, 9 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 54 Tested
Inhibition of HDAC (unknown origin)
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Assay data:16 Active, 8 Activity ≤ 1 µM, 18 Tested
Inhibition of human HDAC2 incubated for 30 mins by SpectraMax M2 microplate reader analysis
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of HDAC (unknown origin) by H4 Hybrid Multi-Mode Microplate Reade
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of HDAC2 (unknown origin) using trypsin and LGK(Ac)-AMC as substrates incubated for 1 hr and measured by fluorescence assay
Inhibition of full length human recombinant HDAC2 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method
Assay data:1 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H4K5 at 5 uM preincubated for 6 hrs followed by compound washout and measured up to 48 hrs by Western blot analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H3K9 at 5 uM preincubated for 6 hrs followed by compound washout and measured up to 48 hrs by Western blot analysis
Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H4K5 at 5 uM treated for 48 hrs by Western blot analysis
Assay data:4 Tested
Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H3K9 at 5 uM treated for 48 hrs by Western blot analysis
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