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Agonist activity at human TRPM5 expressed in human Caco-2 cells assessed as increase in acetylcholine release at 50 uM incubated for 18 hrs in the presence of N'-(3,4-dimethoxybenzylidene)-2-(naphthalen-1-yl)acetohydrazide by mass spectrometric analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human TRPM5 expressed in human Caco-2 cells assessed as increase in acetylcholine release at 50 uM incubated for 18 hrs in the presence of N'-(3,4-dimethoxybenzylidene)-2-phenylcyclopropanecarbohydrazide by mass spectrometric analysis
Agonist activity at human TRPM5 expressed in human Caco-2 cells assessed as increase in acetylcholine release at 50 uM incubated for 18 hrs by mass spectrometric analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human TRPM5 expressed in CHO-K1 cells assessed as increase in relative fluorescence unit measured for 2 mins by FLIPR based membrane potential assay
Assay data:24 Active, 15 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human TRPM5 in HEK293T cells by FLIPR based assay
Assay data:1 Tested
Agonist activity at human TRPM5 expressed in HEK cells by whole cell electrophysiology method
Assay data:1 Active, 1 Tested
Antagonist activity at TRPM5 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at TRPM5 (unknown origin)
Agonist activity at human TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by QPatch HTX assay
Agonist activity at human TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assay
Assay data:46 Active, 25 Activity ≤ 1 µM, 72 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Agonist activity at human TRPM5 expressed in HEK293 cells assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay
Assay data:4 Tested
Inhibition of human TRPM5 expressed in HEK293 cells assessed as decrease in carbachol-evoked membrane depolarization at 22 uM preincubated for 2 mins followed by carbachol addition measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay relative to control
Human TRPM5 (Transient Receptor Potential channels)
Assay data:3 Active, 3 Tested
Inhibition of human TRPM5 transfected in HEK293 cells assessed as inhibition of KCl-stimulated membrane potential by FLIPR assay
Assay data:62 Active, 50 Activity ≤ 1 µM, 68 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human TRPM5 transfected in HEK293 cells assessed as inhibition of ATP-mediated calcium mobilization by Calcium3 dye-based FLIPR assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Induction of human TRPM5 opening expressed in HEK293 cells by FLIPR membrane potential/summary (Abse5) assay
Blocking of human TRPM5 expressed in HEK293 cells by FLIPR membrane potential/summary (Abse5) assay
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
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