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Biochemical Assay from US Patent US20240002365: "PYRIDAZINE AND 1,2,4-TRIAZINE DERIVATIVES AS FGFR KINASE INHIBITORS"
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
FGFR2 Biochemical Caliper Assay from US Patent US11780845: "FGFR inhibitors and methods of use thereof"
Assay data:1057 Active, 1057 Activity ≤ 1 µM, 1441 Tested
Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
FGFR Enzymatic Assay from US Patent US11667635: "Bicyclic heterocycles as FGFR4 inhibitors"
Assay data:37 Active, 37 Activity ≤ 1 µM, 37 Tested
Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"
Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
FGFR2 Activity Inhibition Test from US Patent US11572353: "Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzymatic Assay from US Patent US11542247: "Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer"
Assay data:4 Active, 3 Activity ≤ 1 µM, 10 Tested
FGFR Enzymatic Assay from US Patent US11530214: "Bicyclic heterocycles as FGFR inhibitors"
Assay data:54 Active, 54 Activity ≤ 1 µM, 54 Tested
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays from US Patent US11530183: "Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists"
Assay data:31 Active, 10 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
Inhibition of FGFR2 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assay
Assay data:32 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (SelectScreen (Invitrogen)) EUB0000679a FGFR2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Thermal Shift Assay. Domain: start/stop: T457-E768
Assay data:27 Tested
SummaryRelated BioAssays by Target
Cellular target engagement assay with: FGFR2
Inhibition of recombinant FGFR2 (unknown origin) by mobility assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FGFR2 (unknown origin) using FLT3 as substrate incubated for 30 mins in presence of ATP by time-resolved fluorescence energy-transfer assay
Inhibition of FGFR2 (unknown origin) incubated for 30 mins by trilux reader method
Inhibition of wild type FGFR2 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FGFR2 (unknown origin) at 1 uM in presence of ATP by Z'-LYTE assay relative to control
Assay data:2 Tested
Inhibition of FGFR2 (unknown origin) at upto 10 uM by Z'-LYTE assay
Assay data:1 Tested
Inhibition of FGFR2 (unknown origin) by Z'-LYTE assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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