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Enzymatic IC50 Assays from US Patent US11584755: "Dihydrothieno[3,2-b]pyridine compounds"
Assay data:163 Active, 115 Activity ≤ 1 µM, 165 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzymatic Assay from US Patent US11253521: "3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators"
Assay data:71 Active, 67 Activity ≤ 1 µM, 71 Tested
Steady-State Kinetics from Article 10.1038/nchembio.2148: "Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site."
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding Assay from US Patent US9745328: "Flap modulators"
Assay data:801 Active, 94 Activity ≤ 1 nM, 763 Activity ≤ 1 µM, 885 Tested
Binding Assay from US Patent US9732093: "FLAP modulators"
Assay data:331 Active, 6 Activity ≤ 1 nM, 315 Activity ≤ 1 µM, 353 Tested
Inhibition of nuclease activity of FEN1 (unknown origin) up to 125 uM using DNA substrate
Assay data:1 Tested
SummaryRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of FEN1 (unknown origin)
Assay data:22 Active, 10 Activity ≤ 1 µM, 38 Tested
Assay data:41 Tested
SummaryPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Break-induced replication repair of damaged forks induces genomic duplications in human cells
Assay data:478 Active, 1380 Tested
qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds
Assay data:696 Active, 7 Activity ≤ 1 µM, 882 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
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