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Biochemical Assay from US Patent US11884660: "Substituted oxopyridine derivative"
Assay data:2 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Enzymatic Activity Assay from US Patent US20230391761: "SUBSTITUTED S-ALANINATE DERIVATIVES"
Assay data:17 Active, 14 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Factor XIa Inhibition Assay Utilizing a Fluorophore-Quencher Pair Peptide Substrate from US Patent US20230295157: "3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS"
Assay data:341 Active, 112 Activity ≤ 1 nM, 356 Activity ≤ 1 µM, 357 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Factor XIa Assay from US Patent US20230286958: "PLASMA KALLIKREIN INHIBITORS"
Assay data:136 Active, 63 Activity ≤ 1 µM, 185 Tested
Factor XIa Enzyme Inhibition Assay from US Patent US11691962: "Therapeutic compounds and compositions"
Assay data:214 Active, 217 Activity ≤ 1 µM, 217 Tested
Determination of the % Inhibition for FXIa from US Patent US11613527: "Enzyme inhibitors"
Assay data:8 Active, 4 Activity ≤ 1 µM, 109 Tested
Biological Assay from US Patent US11584735: "Solid forms of a plasma kallikrein inhibitor and salts thereof"
Inhibition of Coagulation Factor XIa from US Patent US11541049: "Tetrahydroisoquinoline derivatives, preparation process and use thereof"
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Selectivity interaction (Serine protease panel) EUB0000735a F11
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human plasma coagulation factor XIa assessed as remaining enzyme activity using Boc-Glu(OBzl)-Ala-Arg-MCA as substrate at 10 uM preincubated for 5 to 15 mins followed by substrate addition and measured at 5 mins interval for 2 hrs by fluorescence based envision plate reader method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence based assay
Assay data:22 Active, 13 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human plasma coagulation factor XIa using Boc-Glu(OBzl)-Ala-Arg-MCA as substrate preincubated for 5 to 15 mins followed by substrate addition and measured at 5 mins interval for 2 hrs by fluorescence based envision plate reader method
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human coagulation factor XIa using GPR-AFC as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 mins
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of human factor 11a preincubated for 5 mins followed by substrate addition by fluorometer analysis
Inhibition of coagulation factor XIa (unknown origin) assessed as chromogenic substrate hydrolysis using CS-21(66) as substrate incubated for 1 hr by spectrophotometer based microplate reader method
Assay data:16 Active, 16 Activity ≤ 1 µM, 40 Tested
Inhibition of coagulation factor XIa (unknown origin) assessed as chromogenic substrate hydrolysis using CS-21(66) as substrate at 50 nM incubated for 1 hr by spectrophotometer based microplate reader method relative to control
Assay data:40 Tested
Binding affinity to human coagulation factor 11a using L-Pyroglutamyl-L-prolyl-L-arginine p-Nitroaniline as substrate assessed as inhibition constant measured upto 120 mins by spectrophotometric analysis
Assay data:17 Active, 6 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Inhibition of human coagulation factor 11 assessed as inhibition of factor 12a mediated activation measured after 60 mins by fluorescence based microplate reader assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of human coagulation factor 11 assessed as inhibition of factor 12a mediated activation using z-GPR-AFC measured after 60 mins by fluorescence assay
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