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Human D1 Receptor PAM Assay from US Patent US20230382869: "Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Radioligand Binding Assay from US Patent US11642336: "5-HT2A agonists for use in treatment of depression"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000342a DRD1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000335a DRD1
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a DRD1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000138c DRD1
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a DRD1
Binding affinity to D1 receptor (unknown origin) at 10000 nM by radioligand displacement assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of dopamine D1 receptor (unknown origin) at 10 uM relative to control
Antagonist activity at human D1 receptor at 10 uM relative to control
Agonist activity at human D1 receptor at 10 uM relative to control
Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane at 10 uM by competitive inhibition based analysis
Assay data:54 Tested
Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of D1 receptor (unknown origin)
Assay data:4 Tested
Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as maximal cAMP accumulation by HTRF assay
Assay data:3 Tested
Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Agonist activity at dopamine D1 receptor (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Positive allosteric modulation of D1R (unknown origin) expressed in human SK-N-MC cells assessed as effect on cAMP production pretreated with compound for 15 mins absence of dopamine measured after 15 mins by HTRF assay
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