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Inhibition of biotinylated recombinant human PARP15 expressed in Escherichia coli BL21 (DE3)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PARP15 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of N-terminal his-tagged human PARP15 expressed in Escherichia coli Rosette2 (DE3)
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PARP15 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human N-terminal 6His-tagged PARP15 (460 to 656 residues) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ as substrate incubated for 10 mins by fluorescence based analysis
Assay data:18 Active, 6 Activity ≤ 1 µM, 22 Tested
Inhibition of N-terminal His-tagged human PARP15 catalytic domain expressed in Escherichia coli BL21 (DE3) preincubated with 6-a-NAD+ for 5 to 10 mins followed by enzyme addition and measured after 60 mins using NAD+ as substrate byHRP based chemiluminescence assay
Assay data:1 Active, 1 Tested
Inhibition of N-terminal His-tagged human PARP15 catalytic domain expressed in Escherichia coli BL21 (DE3) at 10 uM preincubated with 6-a-NAD+ for 5 to 10 mins followed by enzyme addition and measured after 60 mins using NAD+ as substrate byHRP based chemiluminescence assay
Assay data:5 Tested
Inhibition of TEV cleavage site fused N-terminal 6His-tagged PARP15 (482 to 678 residues) (unknown origin) expressed in Escherichia coli Rosetta2 (DE3)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PARP15 (482 to 678 residues) (unknown origin) expressed in Escherichia coli using NAD+ as substrate incubated for 3 hrs by fluorescence based assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 7 Tested
Assay data:2 Tested
Enzymatic Activity Assay from Article 10.1016/j.chembiol.2016.08.012: "Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage."
Inhibition of N-terminal His-tagged human PARP15 catalytic domain (481 to 678 residues) expressed in Escherichia coli BL21 (DE3) cells up to 100 uM in presence of NAD+ incubated for 2 hrs by M-ELISA plate method
Assay data:4 Active, 8 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of N-terminal GST-tagged human PARP15 (221 to 444 residues) expressed in Escherichia coli assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control
Inhibition of N-terminal His-tagged human ARTD7 (482 to 678 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 3 hrs in presence of NAD+
Inhibition of PARP15 (unknown origin) using biotin-NAD+, NAD+ and sIDNA as substrate at 5 uM incubated for 1 hr by ELISA relative to control
Inhibition of human N-terminal GST-tagged PARP15 (221 to 444 residues) expressed in Escherichia coli using biotinylated substrate by chemiluminescence method
Inhibition of human PARP15 catalytic domain assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of full length recombinant His6-tagged PARP15 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence based assay
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