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Inhibition of human CYP11B1 expressed in V79 cells using 11-deoxycorticosteron as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by HPLC analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human CYP11B1 expressed in Chinese hamster V79 MZh cells using [14C]-deoxycorticosteron as substrate measured after 6 hrs by phosphoimager analysis
Assay data:37 Active, 37 Activity ≤ 1 µM, 37 Tested
Enzyme Assay from US Patent US11040034: "Metalloenzyme inhibitor compounds"
Assay data:133 Active, 113 Activity ≤ 1 µM, 135 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Cortisol Synthesis from US Patent US10858342: "Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases"
Assay data:112 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
G402-Based Assay from US Patent US9458135: "Dihydroquinoline-2-one derivatives"
Assay data:30 Active, 20 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
Cellular Inhibition Assay from US Patent US9394290: "Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases"
Assay data:44 Active, 1 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 46 Tested
Cellular Enzyme Assay from US Patent US9353081: "Bicyclic dihydroquinoline-2-one derivatives"
Assay data:46 Active, 41 Activity ≤ 1 µM, 46 Tested
V79-Human-CYP11B2 and V79-Human-CYP11B1 Assays from US Patent US9351973: "Pyrazolopyridyl compounds as aldosterone synthase inhibitors"
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
In Vitro Inhibition Assay from US Patent US9271963: "Selective inhibitors of human corticosteroid synthases"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Assay from US Patent US9271963: "Selective inhibitors of human corticosteroid synthases"
Assay data:27 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested
Inhbition Assay from US Patent US9278093: "Aldosterone synthase inhibitors"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Cellular Enzyme Assay from US Patent US9187429: "Phenyl-tetrahydroisoquinoline derivatives"
Assay data:72 Active, 1 Activity ≤ 1 nM, 69 Activity ≤ 1 µM, 72 Tested
CYP11B1 Inhibition Assay from Article 10.1021/jm800355c: "Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer."
Assay data:16 Active, 12 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
CYP17 Inhibition Assay from Article 10.1021/jm800355c: "Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer."
Assay data:21 Active, 14 Activity ≤ 1 µM, 22 Tested
HTRF-Based Assay from US Patent US9844553: "Pyrazolopyridyl compounds as aldosterone synthase inhibitors"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Inhibition Assay from US Patent US9796702: "Dihydroquinoline pyrazolyl compounds"
Assay data:23 Active, 23 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested
Inhibition Assay from US Patent US9790217: "Pyridinyloxy- and phenyloxy-pyrazolyl compounds"
Assay data:85 Active, 80 Activity ≤ 1 nM, 85 Activity ≤ 1 µM, 85 Tested
Inhibition Assay from US Patent US9745289: "Aldosterone synthase inhibitors"
Assay data:61 Active, 61 Activity ≤ 1 µM, 62 Tested
G402-Based Assay from US Patent US9636339: "Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors"
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
Enzymatic Activity Assay from US Patent US9636338: "Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthase"
Assay data:23 Active, 21 Activity ≤ 1 µM, 23 Tested
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