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Synergistic activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells at 10 uM incubated for 48 hrs in presence of DZNep
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of Tat-mediated HIV1 transcription in CD4 positive cells derived from HIV-infected patient on suppressive anti-retroviral therapy assessed as increase in unspliced HIV transcripts at 1 uM incubated for 72 hrs by RT-qPCR method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as maximum LTR activity at 0.1 uM incubated for 48 hr by FACSCalibur flow cytometry relative to control
Assay data:1 Tested
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as maximum LTR activity at 0.01 uM incubated for 48 hr by FACSCalibur flow cytometry relative to control
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as maximum LTR activity at 5 uM incubated for 48 hr by FACSCalibur flow cytometry relative to control
Assay data:3 Tested
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as maximum LTR activity at 2.5 uM incubated for 48 hr by FACSCalibur flow cytometry relative to control
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as maximum LTR activity at 10 uM incubated for 48 hr by FACSCalibur flow cytometry relative to control
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as maximum LTR activity at 20 uM incubated for 48 hr by FACSCalibur flow cytometry relative to control
Assay data:6 Tested
Synergistic activation of Tat-mediated HIV1 transcription in in CD4 positive cells derived from HIV-infected patient on suppressive anti-retroviral therapy at 2.5 uM incubated for 72 hrs in presence of JQ1
Activation of Tat-mediated HIV1 transcription in CD4 positive cells derived from HIV-infected patient on suppressive anti-retroviral therapy assessed as increase in unspliced HIV transcripts at 2.5 uM incubated for 72 hrs by RT-qPCR method relative to control
Synergistic activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells at 10 uM incubated for 48 hrs in presence of DZNep relative to compound alone
Synergistic activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells at 10 uM incubated for 48 hrs in presence of PFI-1
Assay data:2 Active, 2 Tested
Synergistic activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells at 10 uM incubated for 48 hrs in presence of JQ1
Assay data:1 Active, 2 Tested
Synergistic activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells at 10 uM incubated for 48 hrs in presence of PFI-1
Synergistic activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells at 10 uM incubated for 48 hrs in presence of JQ1
Synergistic activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells at 10 uM incubated for 48 hrs in presence of Ricolinostat
Synergistic activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells at 10 uM incubated for 48 hrs in presence of Ricolinostat
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as LTR-driven gene expression incubated for 48 hr by FACSCalibur flow cytometry
Assay data:6 Active, 2 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as maximum LTR activity at 0.2 uM incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay relative to control
Activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as maximum LTR activity at 0.005 uM incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay relative to control
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