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Inhibition of thioredoxin reductase in human A549/CDDP cells by DTNB dye based microplate spectrophotometry
Assay data:5 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of thioredoxin reductase in human A549 cells by DTNB dye based microplate spectrophotometry
Inhibition of thioredoxin reductase (unknown origin) after 2 hrs by DTNB dye based microplate spectrophotometry
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of TRR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay
Assay data:9 Tested
SummaryRelated BioAssays by Target
Inhibition of TrxR in human SGC7901 cells assessed as p38 phosphorylation at 1200 nM after 48 hrs in presence of NAC by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TrxR in human SGC7901 cells assessed as JNK phosphorylation at 1200 nM after 48 hrs in presence of NAC by Western blot analysis
Inhibition of TrxR in human SGC7901 cells assessed as p38 phosphorylation at 600 to 1200 nM after 48 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of TrxR in human SGC7901 cells assessed as JNK phosphorylation at 600 to 1200 nM after 48 hrs by Western blot analysis
Inhibition of TrxR in human SGC7901 cells assessed as induction of intracellular ROS generation at 800 to 1000 nM after 5 hrs in presence of NAC by DCFH-DA staining based flow cytometric analysis
Inhibition of TrxR in human SGC7901 cells assessed as induction of intracellular ROS generation by DCFH-DA staining based flow cytometric analysis
Irreversible inhibition of thioredoxin reductase (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Increase in thioredoxin reductase activity in HEK293 cells at 0.0625 to 0.625 uM after 24 hrs by DTNB reduction assay
Assay data:2 Tested
Inhibition of thioredoxin reductase activity in human MCF7 cells at 20 uM after 24 hrs by DTNB reduction assay
Inhibition of thioredoxin reductase activity in human MCF7 cells after 24 hrs by DTNB reduction assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrs
Assay data:1 Active, 2 Tested
Inhibition of TrxR in human HeLa cells after 48 hrs by TRFS-green based fluorescence microscopy
Inhibition of TrxR in human HeLa cells after 48 hrs by end point reduction assay
In vitro inhibition of TrxR U498C mutant (unknown origin) up to 40 uM after 2 hrs incubation by microplate reader
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