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NACH/H Eurofins SafetyScreen44 (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at nAChR in human PC-3 cells assessed as reduction in cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at nAChR in human HT-29 cells assessed as reduction in cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
Antagonist activity at nAChR in human MDA-MB-231 cells assessed as reduction cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
Inhibition of neuronal nicotinic receptor (unknown origin) at 0.1 to 1 uM
Inhibition of human nAChR at 10 uM relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human nicotinic acetylcholine receptor alpha5 subunit (Nicotinic acetylcholine receptors)
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Binding affinity to alpha3beta4alpha5 nAChR (unknown origin)
Assay data:1 Active, 1 Tested
Positive allosteric modulation of human alpha4beta2alpha5 nACHR expressed in HEK-tsA201 cells assessed as potentiation of nicotine-induced current at 1 uM preincubated for 15 mins followed by nicotine-treatment by fluorometric analysis
Assay data:47 Tested
Positive allosteric modulation of human alpha4beta2alpha5 nACHR expressed in HEK-tsA201 cells assessed as potentiation of nicotine-induced current preincubated for 15 mins followed by nicotine-treatment by fluorometric analysis
Assay data:8 Active, 4 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of human alpha4beta2alpha5 nACHR expressed in HEK-tsA201 cells assessed as potentiation of nicotine-induced current preincubated for 15 mins followed by nicotine-treatment by fluorometric analysis relative to NS9283
Assay data:7 Tested
Positive allosteric modulation of human alpha3beta4alpha5 nACHR expressed in HEK-tsA201 cells assessed as potentiation of nicotine-induced current preincubated for 15 mins followed by nicotine-treatment by fluorometric analysis
Assay data:2 Tested
Positive allosteric modulation of human alpha3beta2alpha5 nACHR expressed in HEK-tsA201 cells assessed as potentiation of nicotine-induced current preincubated for 15 mins followed by nicotine-treatment by fluorometric analysis
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