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Biological Assay from US Patent US11512066: "Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases"
Assay data:107 Active, 47 Activity ≤ 1 µM, 107 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Aequorin-Based Luminescent Assay from US Patent US10780095: "Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists"
Assay data:25 Active, 25 Activity ≤ 1 µM, 25 Tested
Biological Assay from US Patent US10562882: "Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions"
Assay data:39 Active, 14 Activity ≤ 1 µM, 41 Tested
BIOLOGICAL ASSAY from US Patent US10544126: "Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases"
Biological Assay from US Patent US9475795: "Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases"
BIOLOGICAL ASSAY from US Patent US10335402: "Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders"
Assay data:23 Active, 17 Activity ≤ 1 µM, 23 Tested
Receptor Binding Assay from Article 10.1021/jm800854e: "Triazine Compounds as Antagonists at Bv8-Prokineticin Receptors."
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Biological Assay from US Patent US9790201: "Piperidine and azepine derivatives as prokineticin receptor modulators"
Assay data:113 Active, 65 Activity ≤ 1 µM, 113 Tested
BIOLOGICAL ASSAY from US Patent US10167273: "Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases"
PRESTO-Tango GPCRome screening (PK1)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activity at human PK1 receptor at 10 uM
SummaryPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human PKR1 (Prokineticin receptors)
Assay data:10 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human PKR1 expressed in RBL2H3 cells assessed as inhibition of prokineticin1-mediated intracellular calcium release preincubated for 10 mins followed by PK1 addition by FLIPR assay
Antagonist activity at human PKR1 expressed in rat RBL2H3 cells assessed as inhibition of PK1-stimulated intracellular calcium release incubated for 10 mins prior to PK1 stimulation by FLIPR assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 6 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
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