Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Heparanase Inhibition Assay from US Patent US11718609: "Heparanase inhibitors and use thereof"
Assay data:8 Active, 2 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Substrate activity at heparanase (unknown origin) assessed as formation of saccharide hemiacetal product at 100 uM measured at 111 hrs by WST1 dye based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Substrate activity at heparanase (unknown origin) assessed as formation of saccharide hemiacetal product at 100 uM measured over 24 hrs by WST1 dye based assay
Assay data:4 Active, 5 Tested
Inhibition of heparanase (unknown origin) assessed as reduction in ROS-mediated ERO1alpha mRNA level in mouse MIN6 cells co-incubated with heparanase-producing CHO cells at 15 uM incubated for 24 hrs by qRT-PCR analysis
Inhibition of heparanase (unknown origin) assessed as reduction in ROS-mediated SOD1 mRNA level in mouse MIN6 cells co-incubated with heparanase-producing CHO cells at 15 uM incubated for 24 hrs by qRT-PCR analysis
Inhibition of human recombinant heparanase assessed as reduction in [35S] labeled ECM degradation at 10 ug/ml incubated for 5 hrs relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant heparanase assessed as reduction in [35S] labeled ECM degradation at 50 ug/ml incubated for 5 hrs relative to control
Inhibition of heparanase (unknown origin) using biotin-heparan sulfate-Eu cryptate as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by TR-FRET assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HPSE in human HT1080 cells assessed as reduction in MM9 mRNA expression at 1 uM after 24 hrs by qPCR analysis
Assay data:2 Active, 2 Tested
Inhibition of HPSE in human HT1080 cells assessed as reduction in VEGF mRNA expression at 1 uM after 24 hrs by qPCR analysis
Inhibition of HPSE in human HT1080 cells assessed as reduction in FGF-2 mRNA expression at 1 uM after 24 hrs by qPCR analysis
Assay data:1 Active, 2 Tested
Inhibition of HPSE in human HT1080 cells assessed as reduction in FGF-1 mRNA expression at 1 uM after 24 hrs by qPCR analysis
Inhibition of recombinant HPSE GS3 (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 based colorimetry
Assay data:13 Active, 4 Activity ≤ 1 µM, 17 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of HPSE in human HT1080 cells assessed as reduction in HPSE mRNA expression after 24 hrs by qPCR analysis relative to control
Assay data:2 Active, 4 Tested
Inhibition of HPSE in human HT1080 cells assessed as reduction in MMP9 mRNA expression after 24 hrs by qPCR analysis relative to control
Inhibition of HPSE in human HT1080 cells assessed as reduction in VEGF mRNA expression after 24 hrs by qPCR analysis relative to control
Inhibition of HPSE in human HT1080 cells assessed as reduction in FGF2 mRNA expression after 24 hrs by qPCR analysis relative to control
Inhibition of HPSE in human HT1080 cells assessed as reduction in FGF1 mRNA expression after 24 hrs by qPCR analysis relative to control
Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assay
Assay data:22 Active, 12 Activity ≤ 1 µM, 36 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on