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Inhibition of OATP1B1 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:6 Active, 2 Activity ≤ 1 µM, 9 Tested
Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells assessed as reduction in OATP 1B1-mediated [3H]-pitavastatin uptake preincubated for 30 mins followed by [3H]-pitavastatin addition and measured after 2 mins by liquid scintillation analysis
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
In Vitro Uptake Transporter Assay from US Patent US9090657: "Compound and methods for its production"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:7 Active, 6 Activity ≤ 1 µM, 8 Tested
Inhibition of OATP1B1 (unknown origin) at 500 nM
Assay data:7 Tested
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells
Inhibition of human OATP1B1-mediated [3H]-Estrone sulfate uptake expressed in human HepG2 cells at 2 uM
Assay data:6 Tested
Inhibition of human OATP1B1 assessed as reduction in intracellular probe substrate accumulation upto 100 uM by microplate scintillation counter analysis relative to control
Substrate activity at OATP1B1 (unknown origin) expressed in HEK293 cells assessed as ratio of drug uptake in absence of transporter inhibitor,estradiol-17beta-glucuronide to drug uptake in presence of transporter inhibitor, estradiol-17beta-glucuronide by LC-MS/MS analysis
Assay data:2 Tested
Inhibition of human OATP1B1 assessed as reduction in OATP1B1- mediated E217betaG transport at 14900 uM relative to control
Inhibition of human OATP1B1
Inhibition of OATP1B1 (unknown origin) at upto 3 uM
Inhibition of OATP1B1 (unknown origin) mediated [3H]-estrone sulfate uptake expressed in human HepG2 cells
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of OATP1B1 (unknown origin) at 1 to 10 uM
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