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Binding affinity to Streptococcus pneumoniae PBP2x
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid
Assay data:36 Active, 44 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Homogeneous Enzyme Assay with SPA Beads from Article 10.1016/j.bmcl.2005.03.003: "Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase."
Assay data:43 Active, 43 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from Article : "AR-709-An Investigational diaminopyrimidine: Inhibition, Binding and Mode of Action."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2003.07.023: "Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria."
Antagonist activity against CSP2-mediated pneumolysin release in Streptococcus pneumoniae TIGR4 assessed as inhibition of autolytic release of pneumolysin at 46 to 368 nM in presence of CSP2 by Western blot analysis
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at ComD2 receptor in Streptococcus pneumoniae TIGR4 harboring pcomX/lacZ reporter gene assessed as inhibition of CSP2-stimulated maximum signal preincubated for 30 mins followed by 250 nM native CSP2 addition by ONPG based beta-galactosidase assay
Assay data:1 Active, 3 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Agonist activity at ComD2 receptor in Streptococcus pneumoniae TIGR4 harboring pcomX/lacZ reporter gene incubated for 30 mins by ONPG based beta-galactosidase assay
Assay data:7 Active, 15 Activity ≤ 1 µM, 30 Tested
Inhibition of Streptococcus pneumoniae VicK preincubated for 30 mins followed by [gamma-33P]ATP addition after 30 mins by SDS-PAGE method
Assay data:2 Tested
SummaryPubMed Citation
Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay
Assay data:40 Active, 32 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 40 Tested
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's method
Assay data:5 Active, 1 Activity ≤ 1 µM, 38 Tested
Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2x after 60 mins by SDS-PAGE
Assay data:1 Active, 1 Tested
Inhibition of Streptococcus pneumoniae SP-3 gyrB by enzyme coupled phosphate assay
Assay data:35 Active, 33 Activity ≤ 1 µM, 35 Tested
Inhibition of Streptococcus pneumoniae UPPS
Assay data:27 Active, 16 Activity ≤ 1 µM, 32 Tested
Inhibition of Streptococcus pneumoniae MTAN
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of trimethoprim-resistant Streptococcus pneumoniae DHFR I100L mutant
Assay data:3 Tested
Inhibitory concentration against Streptococcus pneumoniae Phenylalanyl-tRNA synthetase
Assay data:3 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibitory concentration against Streptococcus pneumoniae chorismate synthase
Assay data:31 Active, 11 Activity ≤ 1 µM, 41 Tested
Inhibition of Streptococcus pneumoniae pneumolysin-mediated lysis of Jurkat cells assessed as [51Cr] release at 20 uM preincubated with perforin for 30 mins followed by incubation with [51Cr]-labeled Jurkat cells by gamma counting
Inhibition of Streptococcus pneumoniae seryl tRNA synthetase expressed in Escherichia coli BL21 (DE3) assessed as formation of [3H]seryl tRNA at 100 uM
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