Entry - *614580 - PROGESTIN AND ADIPOQ RECEPTOR FAMILY, MEMBER 9; PAQR9 - OMIM

 
 
* 614580

PROGESTIN AND ADIPOQ RECEPTOR FAMILY, MEMBER 9; PAQR9


HGNC Approved Gene Symbol: PAQR9

Cytogenetic location: 3q23     Genomic coordinates (GRCh38): 3:142,949,164-142,964,008 (from NCBI)


TEXT

▼ Cloning and Expression

By searching databases for sequences encoding a 7-transmembrane domain similar to those of ADIPOR1 (607945) and ADIPOR2 (607946), Tang et al. (2005) identified PAQR9. The deduced 377-amino acid protein shares significant similarity with ADIPOR1 and ADIPOR2 only in the central 7-transmembrane domain region. Database analysis revealed a mouse ortholog, which shares 91% amino acid identity with human PAQR9. RT-PCR analysis detected high PAQR9 expression in human brain, testis, liver, heart, and adult bone marrow. Weaker expression was detected in pancreas, lymph node, kidney, skin, and thymus, and little to no expression was detected in other tissues examined.


▼ Gene Structure

Tang et al. (2005) determined that the PAQR9 gene contains a single coding exon.


▼ Mapping

By genomic sequence analysis, Tang et al. (2005) mapped the PAQR9 gene to chromosome 3q23.


▼ REFERENCES

  1. Tang, Y. T., Hu, T., Arterburn, M., Boyle, B., Bright, J. M., Emtage, P. C., Funk, W. D. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. J. Molec. Evol. 61: 372-380, 2005. [PubMed: 16044242, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 4/18/2012
Edit History:
mgross : 04/19/2012
mgross : 4/18/2012

* 614580

PROGESTIN AND ADIPOQ RECEPTOR FAMILY, MEMBER 9; PAQR9


HGNC Approved Gene Symbol: PAQR9

Cytogenetic location: 3q23     Genomic coordinates (GRCh38): 3:142,949,164-142,964,008 (from NCBI)


TEXT

Cloning and Expression

By searching databases for sequences encoding a 7-transmembrane domain similar to those of ADIPOR1 (607945) and ADIPOR2 (607946), Tang et al. (2005) identified PAQR9. The deduced 377-amino acid protein shares significant similarity with ADIPOR1 and ADIPOR2 only in the central 7-transmembrane domain region. Database analysis revealed a mouse ortholog, which shares 91% amino acid identity with human PAQR9. RT-PCR analysis detected high PAQR9 expression in human brain, testis, liver, heart, and adult bone marrow. Weaker expression was detected in pancreas, lymph node, kidney, skin, and thymus, and little to no expression was detected in other tissues examined.


Gene Structure

Tang et al. (2005) determined that the PAQR9 gene contains a single coding exon.


Mapping

By genomic sequence analysis, Tang et al. (2005) mapped the PAQR9 gene to chromosome 3q23.


REFERENCES

  1. Tang, Y. T., Hu, T., Arterburn, M., Boyle, B., Bright, J. M., Emtage, P. C., Funk, W. D. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. J. Molec. Evol. 61: 372-380, 2005. [PubMed: 16044242] [Full Text: https://doi.org/10.1007/s00239-004-0375-2]


Creation Date:
Patricia A. Hartz : 4/18/2012

Edit History:
mgross : 04/19/2012
mgross : 4/18/2012



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 2, 2024